Abnormalities of sexual differentiation

Evaluation and management

R. H. Reindollar, S. P.T. Tho, P. G. McDonough

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Normal male and female sexual differentiations begins with gametogenesis. Both male and female sexual differentiation follow a timetable of events with predictable development of the gonads, internal genital ducts, and the external genitalia. Completed sexual maturation occurs during the pubertal years. Abnormalities of sexual differentiation may occur at any step along the way. The abnormalities may result in abnormal differentiation of the gonads, the internal genital ducts, or the external genitalia. The end result of these abnormalities produces predictable clinical syndromes. While many of these defects of sexual differentiation are evident at birth, others will not be identified until puberty at which time the patient may manifest aberrant external maturation or may remain sexually infantile. Genital ambiguity in a newborn represents a true medical emergency. Early and expedient diagnosis is essential to avoid life-threatening crises, to determine sex-of-rearing, to provide for appropriate immediate and long-term treatment, and to assure that the family is provided adequate genetic counseling. Medical and surgical treatment should begin during the birth hospitalization and the child should leave the hospital with his or her external genitalia concordant with sex-of-rearing. Finally, the emotional well-being of the familiy unit requires appropriate education and ongoing counseling.

Original languageEnglish (US)
Pages (from-to)697-713
Number of pages17
JournalClinical Obstetrics and Gynecology
Volume30
Issue number3
DOIs
StatePublished - Jan 1 1987

Fingerprint

Sex Differentiation
Genitalia
Gonads
Parturition
Gametogenesis
Disorders of Sex Development
Sexual Maturation
Genetic Counseling
Puberty
Counseling
Early Diagnosis
Hospitalization
Emergencies
Newborn Infant
Education
Therapeutics

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Abnormalities of sexual differentiation : Evaluation and management. / Reindollar, R. H.; Tho, S. P.T.; McDonough, P. G.

In: Clinical Obstetrics and Gynecology, Vol. 30, No. 3, 01.01.1987, p. 697-713.

Research output: Contribution to journalReview article

Reindollar, R. H. ; Tho, S. P.T. ; McDonough, P. G. / Abnormalities of sexual differentiation : Evaluation and management. In: Clinical Obstetrics and Gynecology. 1987 ; Vol. 30, No. 3. pp. 697-713.
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