Absence of Long-Term Gonadotoxicity in Primates Receiving Extracorporeal Shock Wave Application*

Wayne J.G. Hellstrom, Mary Bernice Kaack, Richard M. Harrison, Durwood Earnest Neal, Raju Thomas

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Extracorporeal shock wave lithotripsy (SWL) is becoming popular in the management of lower ureteral calculi; however, the quantity of data on its potential gonadotoxic effects are limited. Eight nonhuman primates had baseline measurements of testicular volume, semen analysis, serum testosterone and FSH assays, and DNA flow cytometric analysis of testicular aspirates. The anesthetized primates were lowered into a Dornier XL-1 lithotripter and at a 20 kV power setting had various numbers of shocks (0,500,1500) directed at each testis. Sequential studies were done at 6-week intervals for 9 months. The control group showed no significant change in any measure. Semen analysis, testosterone, and FSH results were variable and without statistically significant differences. There were changes in the DNA histograms, with the tetraploid (4N) group of cells being the most sensitive. All changes caused by SWL application returned to baseline by 9 months. Data from this primate study document no apparent long-term male gonadotoxicity from SWL, but the authors suggest measures to protect the testis during clinical use.

Original languageEnglish (US)
Pages (from-to)17-21
Number of pages5
JournalJournal of Endourology
Volume7
Issue number1
DOIs
StatePublished - Jan 1 1993
Externally publishedYes

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Lithotripsy
Primates
Semen Analysis
Testosterone
Testis
Ureteral Calculi
Tetraploidy
DNA
Shock
Control Groups
Serum

ASJC Scopus subject areas

  • Urology

Cite this

Absence of Long-Term Gonadotoxicity in Primates Receiving Extracorporeal Shock Wave Application*. / Hellstrom, Wayne J.G.; Kaack, Mary Bernice; Harrison, Richard M.; Neal, Durwood Earnest; Thomas, Raju.

In: Journal of Endourology, Vol. 7, No. 1, 01.01.1993, p. 17-21.

Research output: Contribution to journalArticle

Hellstrom, Wayne J.G. ; Kaack, Mary Bernice ; Harrison, Richard M. ; Neal, Durwood Earnest ; Thomas, Raju. / Absence of Long-Term Gonadotoxicity in Primates Receiving Extracorporeal Shock Wave Application*. In: Journal of Endourology. 1993 ; Vol. 7, No. 1. pp. 17-21.
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