Absence of sperm RNA elements correlates with idiopathic male infertility

Meritxell Jodar, Edward Sendler, Sergey I. Moskovtsev, Clifford L. Librach, Robert Goodrich, Sonja Swanson, Russ Hauser, Michael Peter Diamond, Stephen A. Krawetz

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Semen parameters are typically used to diagnose male infertility and specify clinical interventions. In idiopathic infertile couples, an unknown male factor could be the cause of infertility even when the semen parameters are normal. Next-generation sequencing of spermatozoal RNAs can provide an objective measure of the paternal contribution and may help guide the care of these couples. We assessed spermatozoal RNAs from 96 couples presenting with idiopathic infertility and identified the final reproductive outcome and sperm RNA elements (SREs) reflective of fecundity status. The absence of required SREs reduced the probability of achieving live birth by timed intercourse or intrauterine insemination from 73 to 27%. However, the absence of these same SREs does not appear to be critical when using assisted reproductive technologies such as in vitro fertilization with or without intracytoplasmic sperm injection. About 30% of the idiopathic infertile couples presented an incomplete set of required SREs, suggesting a male component as the cause of their infertility. Conversely, analysis of couples that failed to achieve a live birth despite presenting with a complete set of SREs suggested that a female factor may have been involved, and this was confirmed by their diagnosis. The data in this study suggest that SRE analysis has the potential to predict the individual success rate of different fertility treatments and reduce the time to achieve live birth.

Original languageEnglish (US)
Article number295re6
JournalScience Translational Medicine
Volume7
Issue number295
DOIs
StatePublished - Jul 8 2015

Fingerprint

Male Infertility
Spermatozoa
RNA
Live Birth
Infertility
Semen
RNA Sequence Analysis
Assisted Reproductive Techniques
Intracytoplasmic Sperm Injections
Insemination
Birth Rate
Fertilization in Vitro
Fertility

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Jodar, M., Sendler, E., Moskovtsev, S. I., Librach, C. L., Goodrich, R., Swanson, S., ... Krawetz, S. A. (2015). Absence of sperm RNA elements correlates with idiopathic male infertility. Science Translational Medicine, 7(295), [295re6]. https://doi.org/10.1126/scitranslmed.aab1287

Absence of sperm RNA elements correlates with idiopathic male infertility. / Jodar, Meritxell; Sendler, Edward; Moskovtsev, Sergey I.; Librach, Clifford L.; Goodrich, Robert; Swanson, Sonja; Hauser, Russ; Diamond, Michael Peter; Krawetz, Stephen A.

In: Science Translational Medicine, Vol. 7, No. 295, 295re6, 08.07.2015.

Research output: Contribution to journalArticle

Jodar, M, Sendler, E, Moskovtsev, SI, Librach, CL, Goodrich, R, Swanson, S, Hauser, R, Diamond, MP & Krawetz, SA 2015, 'Absence of sperm RNA elements correlates with idiopathic male infertility', Science Translational Medicine, vol. 7, no. 295, 295re6. https://doi.org/10.1126/scitranslmed.aab1287
Jodar M, Sendler E, Moskovtsev SI, Librach CL, Goodrich R, Swanson S et al. Absence of sperm RNA elements correlates with idiopathic male infertility. Science Translational Medicine. 2015 Jul 8;7(295). 295re6. https://doi.org/10.1126/scitranslmed.aab1287
Jodar, Meritxell ; Sendler, Edward ; Moskovtsev, Sergey I. ; Librach, Clifford L. ; Goodrich, Robert ; Swanson, Sonja ; Hauser, Russ ; Diamond, Michael Peter ; Krawetz, Stephen A. / Absence of sperm RNA elements correlates with idiopathic male infertility. In: Science Translational Medicine. 2015 ; Vol. 7, No. 295.
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