Abstract 16627: Coronary Artery Calcium Scoring and Cardiovascular Events in Patients With Cancer: Analysis of CLARIFY Registry

Sadeer Al-Kindi, Nour Tashtish, Avirup Guha, Imran Rashid, Miguel Cainzos Achirica, Khurram Nasir, Sanjay Rajagopalan

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Cardiovascular disease and cancer co-exist due to shared risk factors. The utility of coronary artery calcium (CAC) scoring in this population to predict cardiovascular events is not certain. Methods: We studied all patients enrolled in the CLARIFY registry of no-charge CAC (Clinicaltrials.gov NCT04075162) with diagnosis of any cancer. We followed patients for major adverse cardiovascular events (myocardial infarction, stroke, heart failure, coronary revascularization or mortality). Results: A total of 3,432 patients with cancer were identified. Mean age was 64±9 years, 1965 (57%) were women and 2937 (86%) were white. Overall distribution of CAC scores were as follows: CAC 0 in 35%, CAC 1-99 in 31%, CAC 100-399 in 20%, and CAC ≥ 400 in 15%. CAC distribution varied by cancer type (figure A). At a median follow-up of 663 [294-1086] days, 343 patients had MACE event. Compared with CAC 0, patients with CAC ≥ 400 had increased unadjusted risk of MACE (HR 2.57 [1.93-3.41], P
Original languageEnglish (US)
JournalCirculation
Volume142
Issue numberSuppl_3
DOIs
StatePublished - Nov 17 2020

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