TY - JOUR
T1 - Abstract 16627: Coronary Artery Calcium Scoring and Cardiovascular Events in Patients With Cancer: Analysis of CLARIFY Registry
AU - Al-Kindi, Sadeer
AU - Tashtish, Nour
AU - Guha, Avirup
AU - Rashid, Imran
AU - Cainzos Achirica, Miguel
AU - Nasir, Khurram
AU - Rajagopalan, Sanjay
PY - 2020/11/17
Y1 - 2020/11/17
N2 - Introduction: Cardiovascular disease and cancer co-exist due to shared risk factors. The utility of coronary artery calcium (CAC) scoring in this population to predict cardiovascular events is not certain. Methods: We studied all patients enrolled in the CLARIFY registry of no-charge CAC (Clinicaltrials.gov NCT04075162) with diagnosis of any cancer. We followed patients for major adverse cardiovascular events (myocardial infarction, stroke, heart failure, coronary revascularization or mortality). Results: A total of 3,432 patients with cancer were identified. Mean age was 64±9 years, 1965 (57%) were women and 2937 (86%) were white. Overall distribution of CAC scores were as follows: CAC 0 in 35%, CAC 1-99 in 31%, CAC 100-399 in 20%, and CAC ≥ 400 in 15%. CAC distribution varied by cancer type (figure A). At a median follow-up of 663 [294-1086] days, 343 patients had MACE event. Compared with CAC 0, patients with CAC ≥ 400 had increased unadjusted risk of MACE (HR 2.57 [1.93-3.41], P
AB - Introduction: Cardiovascular disease and cancer co-exist due to shared risk factors. The utility of coronary artery calcium (CAC) scoring in this population to predict cardiovascular events is not certain. Methods: We studied all patients enrolled in the CLARIFY registry of no-charge CAC (Clinicaltrials.gov NCT04075162) with diagnosis of any cancer. We followed patients for major adverse cardiovascular events (myocardial infarction, stroke, heart failure, coronary revascularization or mortality). Results: A total of 3,432 patients with cancer were identified. Mean age was 64±9 years, 1965 (57%) were women and 2937 (86%) were white. Overall distribution of CAC scores were as follows: CAC 0 in 35%, CAC 1-99 in 31%, CAC 100-399 in 20%, and CAC ≥ 400 in 15%. CAC distribution varied by cancer type (figure A). At a median follow-up of 663 [294-1086] days, 343 patients had MACE event. Compared with CAC 0, patients with CAC ≥ 400 had increased unadjusted risk of MACE (HR 2.57 [1.93-3.41], P
UR - https://www.mendeley.com/catalogue/12f218c4-05d0-3646-af4d-c879efb42cc4/
U2 - 10.1161/circ.142.suppl_3.16627
DO - 10.1161/circ.142.suppl_3.16627
M3 - Article
SN - 0009-7322
VL - 142
JO - Circulation
JF - Circulation
IS - Suppl_3
ER -