Accelerated cognitive aging in diabetic rats is prevented by lowering corticosterone levels

Alexis Michelle Stranahan, Kim Lee, Paul J. Pistell, Christopher M. Nelson, Nathaniel Readal, Marshall G. Miller, Edward L. Spangler, Donald K. Ingram, Mark P. Mattson

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Diabetes and normal aging are both characterized by increases in levels of glucocorticoids. Because long-term exposure to elevated glucocorticoids can be detrimental to hippocampal function, we evaluated the performance of young diabetic rats in the 14-unit T-maze, a task that is sensitive to hippocampal deficits. To assess the contribution of diabetes-induced elevations in corticosterone levels, we examined maze learning in diabetic rats that had levels of corticosterone 'clamped' through adrenalectomy and low-dose corticosterone replacement. For comparison, we also tested a separate group of young and aged rats in the maze. Adrenally intact diabetic rats learned poorly in the 14-unit T-maze. Preventing the increases in corticosterone levels that accompanies the onset of experimental diabetes also prevented deficits in complex maze learning. The pattern of errors made by adrenally intact diabetic rats was similar to the pattern of errors made by aged rats, suggesting that the cognitive profiles of diabetic and aged rats share common features.

Original languageEnglish (US)
Pages (from-to)479-483
Number of pages5
JournalNeurobiology of Learning and Memory
Volume90
Issue number2
DOIs
StatePublished - Sep 1 2008
Externally publishedYes

Fingerprint

Corticosterone
Maze Learning
Glucocorticoids
Adrenalectomy
Cognitive Aging

Keywords

  • Aging
  • Hippocampus
  • Stone maze
  • Streptozocin
  • Stress

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

Accelerated cognitive aging in diabetic rats is prevented by lowering corticosterone levels. / Stranahan, Alexis Michelle; Lee, Kim; Pistell, Paul J.; Nelson, Christopher M.; Readal, Nathaniel; Miller, Marshall G.; Spangler, Edward L.; Ingram, Donald K.; Mattson, Mark P.

In: Neurobiology of Learning and Memory, Vol. 90, No. 2, 01.09.2008, p. 479-483.

Research output: Contribution to journalArticle

Stranahan, AM, Lee, K, Pistell, PJ, Nelson, CM, Readal, N, Miller, MG, Spangler, EL, Ingram, DK & Mattson, MP 2008, 'Accelerated cognitive aging in diabetic rats is prevented by lowering corticosterone levels', Neurobiology of Learning and Memory, vol. 90, no. 2, pp. 479-483. https://doi.org/10.1016/j.nlm.2008.05.005
Stranahan, Alexis Michelle ; Lee, Kim ; Pistell, Paul J. ; Nelson, Christopher M. ; Readal, Nathaniel ; Miller, Marshall G. ; Spangler, Edward L. ; Ingram, Donald K. ; Mattson, Mark P. / Accelerated cognitive aging in diabetic rats is prevented by lowering corticosterone levels. In: Neurobiology of Learning and Memory. 2008 ; Vol. 90, No. 2. pp. 479-483.
@article{4c523369018c4c5cbdba8c613dca942a,
title = "Accelerated cognitive aging in diabetic rats is prevented by lowering corticosterone levels",
abstract = "Diabetes and normal aging are both characterized by increases in levels of glucocorticoids. Because long-term exposure to elevated glucocorticoids can be detrimental to hippocampal function, we evaluated the performance of young diabetic rats in the 14-unit T-maze, a task that is sensitive to hippocampal deficits. To assess the contribution of diabetes-induced elevations in corticosterone levels, we examined maze learning in diabetic rats that had levels of corticosterone 'clamped' through adrenalectomy and low-dose corticosterone replacement. For comparison, we also tested a separate group of young and aged rats in the maze. Adrenally intact diabetic rats learned poorly in the 14-unit T-maze. Preventing the increases in corticosterone levels that accompanies the onset of experimental diabetes also prevented deficits in complex maze learning. The pattern of errors made by adrenally intact diabetic rats was similar to the pattern of errors made by aged rats, suggesting that the cognitive profiles of diabetic and aged rats share common features.",
keywords = "Aging, Hippocampus, Stone maze, Streptozocin, Stress",
author = "Stranahan, {Alexis Michelle} and Kim Lee and Pistell, {Paul J.} and Nelson, {Christopher M.} and Nathaniel Readal and Miller, {Marshall G.} and Spangler, {Edward L.} and Ingram, {Donald K.} and Mattson, {Mark P.}",
year = "2008",
month = "9",
day = "1",
doi = "10.1016/j.nlm.2008.05.005",
language = "English (US)",
volume = "90",
pages = "479--483",
journal = "Neurobiology of Learning and Memory",
issn = "1074-7427",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Accelerated cognitive aging in diabetic rats is prevented by lowering corticosterone levels

AU - Stranahan, Alexis Michelle

AU - Lee, Kim

AU - Pistell, Paul J.

AU - Nelson, Christopher M.

AU - Readal, Nathaniel

AU - Miller, Marshall G.

AU - Spangler, Edward L.

AU - Ingram, Donald K.

AU - Mattson, Mark P.

PY - 2008/9/1

Y1 - 2008/9/1

N2 - Diabetes and normal aging are both characterized by increases in levels of glucocorticoids. Because long-term exposure to elevated glucocorticoids can be detrimental to hippocampal function, we evaluated the performance of young diabetic rats in the 14-unit T-maze, a task that is sensitive to hippocampal deficits. To assess the contribution of diabetes-induced elevations in corticosterone levels, we examined maze learning in diabetic rats that had levels of corticosterone 'clamped' through adrenalectomy and low-dose corticosterone replacement. For comparison, we also tested a separate group of young and aged rats in the maze. Adrenally intact diabetic rats learned poorly in the 14-unit T-maze. Preventing the increases in corticosterone levels that accompanies the onset of experimental diabetes also prevented deficits in complex maze learning. The pattern of errors made by adrenally intact diabetic rats was similar to the pattern of errors made by aged rats, suggesting that the cognitive profiles of diabetic and aged rats share common features.

AB - Diabetes and normal aging are both characterized by increases in levels of glucocorticoids. Because long-term exposure to elevated glucocorticoids can be detrimental to hippocampal function, we evaluated the performance of young diabetic rats in the 14-unit T-maze, a task that is sensitive to hippocampal deficits. To assess the contribution of diabetes-induced elevations in corticosterone levels, we examined maze learning in diabetic rats that had levels of corticosterone 'clamped' through adrenalectomy and low-dose corticosterone replacement. For comparison, we also tested a separate group of young and aged rats in the maze. Adrenally intact diabetic rats learned poorly in the 14-unit T-maze. Preventing the increases in corticosterone levels that accompanies the onset of experimental diabetes also prevented deficits in complex maze learning. The pattern of errors made by adrenally intact diabetic rats was similar to the pattern of errors made by aged rats, suggesting that the cognitive profiles of diabetic and aged rats share common features.

KW - Aging

KW - Hippocampus

KW - Stone maze

KW - Streptozocin

KW - Stress

UR - http://www.scopus.com/inward/record.url?scp=48549104378&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=48549104378&partnerID=8YFLogxK

U2 - 10.1016/j.nlm.2008.05.005

DO - 10.1016/j.nlm.2008.05.005

M3 - Article

C2 - 18579418

AN - SCOPUS:48549104378

VL - 90

SP - 479

EP - 483

JO - Neurobiology of Learning and Memory

JF - Neurobiology of Learning and Memory

SN - 1074-7427

IS - 2

ER -