Acetylcholine's effect on vascular resistance and compliance in the pulmonary circulation

Scott A Barman, E. Senteno, Sylvia B Smith, A. E. Taylor

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Acetylcholine's effect on the distribution of vascular resistance and compliance in the canine pulmonary circulation was determined under control and elevated vascular tone by the arterial, venous, and double occlusion techniques in isolated blood-perfused dog lungs at both constant flow and constant pressure. Large and small blood vessel resistances and compliances were studied in lungs given concentrations of acetylcholine ranging from 2.0 ng/ml to 200 μg/ml. The results of this study indicate that acetylcholine dilates large arteries at low concentrations (≤ 20 ng/ml) and constricts small and large veins at concentrations of at least 2 μg/ml. Characterization of acetylcholine's effects at constant pulmonary blood flow indicates that 1) large artery vasodilation may be endothelial-derived relaxing factor-mediated because the dilation is blocked with methylene blue; 2) a vasodilator of the arachidonic acid cascade (blocked by ibuprofen), probably prostacyclin, lessens acetylcholine's pressor effects; 3) when vascular tone was increased, acetylcholine's hemodynamic effects were attenuated; and 4) acetylcholine decreased middle compartment and large vessel compliance under control but not elevated vascular tone. Under constant pressure at control vascular tone acetylcholine increases resistance in all segments except the large artery, and at elevated vascular tone the pressor effects were enhanced, and large artery resistance was increased.

Original languageEnglish (US)
Pages (from-to)1495-1503
Number of pages9
JournalJournal of Applied Physiology
Volume67
Issue number4
StatePublished - Jan 1 1989
Externally publishedYes

Fingerprint

Pulmonary Circulation
Vascular Resistance
Compliance
Acetylcholine
Blood Vessels
Arteries
Lung
Pressure
Ibuprofen
Methylene Blue
Epoprostenol
Vasodilator Agents
Arachidonic Acid
Vasodilation
Canidae
Dilatation
Veins
Hemodynamics
Dogs

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Acetylcholine's effect on vascular resistance and compliance in the pulmonary circulation. / Barman, Scott A; Senteno, E.; Smith, Sylvia B; Taylor, A. E.

In: Journal of Applied Physiology, Vol. 67, No. 4, 01.01.1989, p. 1495-1503.

Research output: Contribution to journalArticle

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