ACR Appropriateness Criteria® Nonsurgical Treatment for Non-Small-Cell Lung Cancer: Good Performance Status/Definitive Intent

Richard M. Gewanter, Kenneth E. Rosenzweig, Joe Yujiao Chang, Roy Decker, Sarita Dubey, Feng Ming Kong, Brian E. Lally, Corey J. Langer, Hoon Ku Lee, Benjamin Movsas

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The optimal strategy for the non-surgical definitive treatment of patients with good performance status non-small cell lung cancer (mostly with locally advanced disease) has dramatically evolved over time. This article presents evidence-based data to review this literature. Several decades ago, the standard treatment for most stage III inoperable NSCLC was definitive radiation therapy alone. Randomized trials have since shown superior results with sequential chemotherapy and radiation, and more recently with concurrent chemoradiation, the current standard of care. Studies suggest a limited role for induction or adjuvant systemic therapy in addition to concurrent chemoradiation. The role of altered radiation fractionation techniques, such as hyperfractionation for locally advanced disease or hypofractionation for early stage disease is also discussed. More recently, the application of more advanced radiation techniques has been explored, including intensity modulated radiation therapy (IMRT) and proton beam radiation. Finally, various case variants are presented as examples of state-of-the-art treatment approaches.

Original languageEnglish (US)
Pages (from-to)228-249
Number of pages22
JournalCurrent Problems in Cancer
Volume34
Issue number3
DOIs
StatePublished - May 1 2010

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Non-Small Cell Lung Carcinoma
Radiation
Radiotherapy
Therapeutics
Standard of Care
Protons
Drug Therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

ACR Appropriateness Criteria® Nonsurgical Treatment for Non-Small-Cell Lung Cancer : Good Performance Status/Definitive Intent. / Gewanter, Richard M.; Rosenzweig, Kenneth E.; Chang, Joe Yujiao; Decker, Roy; Dubey, Sarita; Kong, Feng Ming; Lally, Brian E.; Langer, Corey J.; Lee, Hoon Ku; Movsas, Benjamin.

In: Current Problems in Cancer, Vol. 34, No. 3, 01.05.2010, p. 228-249.

Research output: Contribution to journalArticle

Gewanter, RM, Rosenzweig, KE, Chang, JY, Decker, R, Dubey, S, Kong, FM, Lally, BE, Langer, CJ, Lee, HK & Movsas, B 2010, 'ACR Appropriateness Criteria® Nonsurgical Treatment for Non-Small-Cell Lung Cancer: Good Performance Status/Definitive Intent', Current Problems in Cancer, vol. 34, no. 3, pp. 228-249. https://doi.org/10.1016/j.currproblcancer.2010.04.001
Gewanter, Richard M. ; Rosenzweig, Kenneth E. ; Chang, Joe Yujiao ; Decker, Roy ; Dubey, Sarita ; Kong, Feng Ming ; Lally, Brian E. ; Langer, Corey J. ; Lee, Hoon Ku ; Movsas, Benjamin. / ACR Appropriateness Criteria® Nonsurgical Treatment for Non-Small-Cell Lung Cancer : Good Performance Status/Definitive Intent. In: Current Problems in Cancer. 2010 ; Vol. 34, No. 3. pp. 228-249.
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