Action Spectra for Ultraviolet Light-Induced Transformation of Human Cells to Anchorage-Independent Growth

Betsy M. Sutherland, Rowena P. Oliver, Neva C. Delihas, John Clark Sutherland

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

We have determined action spectra for transformation of human embryonic skin and muscle fibroblasts to anchorage-independent growth. Tests under our experimental conditions indicate that reciprocity holds for photon rate and exposure time and that all the dose-effect curves in the wavelength range of 248 to 297 nm are similar. These data can be used to construct action spectra with a maximum at about 265 nm, which do not implicate moieties other than nucleic acids as absorbers in the transformation process.

Original languageEnglish (US)
Pages (from-to)2211-2214
Number of pages4
JournalCancer Research
Volume41
Issue number6
StatePublished - Jun 1 1981
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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