Action Spectra for Ultraviolet Light-Induced Transformation of Human Cells to Anchorage-Independent Growth

Betsy M. Sutherland, Rowena P. Oliver, Neva C. Delihas, John C. Sutherland

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

We have determined action spectra for transformation of human embryonic skin and muscle fibroblasts to anchorage-independent growth. Tests under our experimental conditions indicate that reciprocity holds for photon rate and exposure time and that all the dose-effect curves in the wavelength range of 248 to 297 nm are similar. These data can be used to construct action spectra with a maximum at about 265 nm, which do not implicate moieties other than nucleic acids as absorbers in the transformation process.

Original languageEnglish (US)
Pages (from-to)2211-2214
Number of pages4
JournalCancer Research
Volume41
Issue number6
StatePublished - Jun 1 1981
Externally publishedYes

Fingerprint

Ultraviolet Rays
Growth
Photons
Nucleic Acids
Fibroblasts
Muscles
Skin
Action Spectrum

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Action Spectra for Ultraviolet Light-Induced Transformation of Human Cells to Anchorage-Independent Growth. / Sutherland, Betsy M.; Oliver, Rowena P.; Delihas, Neva C.; Sutherland, John C.

In: Cancer Research, Vol. 41, No. 6, 01.06.1981, p. 2211-2214.

Research output: Contribution to journalArticle

Sutherland, Betsy M. ; Oliver, Rowena P. ; Delihas, Neva C. ; Sutherland, John C. / Action Spectra for Ultraviolet Light-Induced Transformation of Human Cells to Anchorage-Independent Growth. In: Cancer Research. 1981 ; Vol. 41, No. 6. pp. 2211-2214.
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