Activation of bone marrow-resident memory T cells by circulating, antigen-bearing dendritic cells

Lois L. Cavanagh, Roberto Bonasio, Irina B. Mazo, Cornelia Halin, Guiying Cheng, Adrianus W.M. van der Velden, Annaiah Cariappa, Catherine Chase, Paul Russell, Michael N. Starnbach, Pandelakis Koni, Shiv Pillai, Wolfgang Weninger, Ulrich H. von Andrian

Research output: Contribution to journalArticle

166 Citations (Scopus)

Abstract

Dendritic cells (DCs) carry antigen from peripheral tissues via lymphatics to lymph nodes. We report here that differentiated DCs can also travel from the periphery into the blood. Circulating DCs migrated to the spleen, liver and lung but not lymph nodes. They also homed to the bone marrow, where they were retained better than in most other tissues. Homing of DCs to the bone marrow depended on constitutively expressed vascular cell adhesion molecule 1 and endothelial selectins in bone marrow microvessels. Two-photon intravital microscopy in bone marrow cavities showed that DCs formed stable antigen-dependent contacts with bone marrow -resident central memory T cells. Moreover, using this previously unknown migratory pathway, antigen-pulsed DCs were able to trigger central memory T cell -mediated recall responses in the bone marrow.

Original languageEnglish (US)
Pages (from-to)1029-1037
Number of pages9
JournalNature Immunology
Volume6
Issue number10
DOIs
StatePublished - Oct 1 2005

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Dendritic Cells
Bone Marrow
T-Lymphocytes
Antigens
Lymph Nodes
Selectins
Vascular Cell Adhesion Molecule-1
Lymphoid Tissue
Microvessels
Photons
Spleen
Lung
Liver

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Cavanagh, L. L., Bonasio, R., Mazo, I. B., Halin, C., Cheng, G., van der Velden, A. W. M., ... von Andrian, U. H. (2005). Activation of bone marrow-resident memory T cells by circulating, antigen-bearing dendritic cells. Nature Immunology, 6(10), 1029-1037. https://doi.org/10.1038/ni1249

Activation of bone marrow-resident memory T cells by circulating, antigen-bearing dendritic cells. / Cavanagh, Lois L.; Bonasio, Roberto; Mazo, Irina B.; Halin, Cornelia; Cheng, Guiying; van der Velden, Adrianus W.M.; Cariappa, Annaiah; Chase, Catherine; Russell, Paul; Starnbach, Michael N.; Koni, Pandelakis; Pillai, Shiv; Weninger, Wolfgang; von Andrian, Ulrich H.

In: Nature Immunology, Vol. 6, No. 10, 01.10.2005, p. 1029-1037.

Research output: Contribution to journalArticle

Cavanagh, LL, Bonasio, R, Mazo, IB, Halin, C, Cheng, G, van der Velden, AWM, Cariappa, A, Chase, C, Russell, P, Starnbach, MN, Koni, P, Pillai, S, Weninger, W & von Andrian, UH 2005, 'Activation of bone marrow-resident memory T cells by circulating, antigen-bearing dendritic cells', Nature Immunology, vol. 6, no. 10, pp. 1029-1037. https://doi.org/10.1038/ni1249
Cavanagh LL, Bonasio R, Mazo IB, Halin C, Cheng G, van der Velden AWM et al. Activation of bone marrow-resident memory T cells by circulating, antigen-bearing dendritic cells. Nature Immunology. 2005 Oct 1;6(10):1029-1037. https://doi.org/10.1038/ni1249
Cavanagh, Lois L. ; Bonasio, Roberto ; Mazo, Irina B. ; Halin, Cornelia ; Cheng, Guiying ; van der Velden, Adrianus W.M. ; Cariappa, Annaiah ; Chase, Catherine ; Russell, Paul ; Starnbach, Michael N. ; Koni, Pandelakis ; Pillai, Shiv ; Weninger, Wolfgang ; von Andrian, Ulrich H. / Activation of bone marrow-resident memory T cells by circulating, antigen-bearing dendritic cells. In: Nature Immunology. 2005 ; Vol. 6, No. 10. pp. 1029-1037.
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