Activation of bone marrow-resident memory T cells by circulating, antigen-bearing dendritic cells

Lois L. Cavanagh; Roberto Bonasio; Irina B. Mazo; Cornelia Halin; Guiying Cheng; Adrianus W.M. van der Velden; Annaiah Cariappa; Catherine Chase; Paul Russell; Michael N. Starnbach; Pandelakis A. Koni; Shiv Pillai; Wolfgang Weninger; Ulrich H. von Andrian

doi:10.1038/ni1249

Activation of bone marrow-resident memory T cells by circulating, antigen-bearing dendritic cells

Lois L. Cavanagh, Roberto Bonasio, Irina B. Mazo, Cornelia Halin, Guiying Cheng, Adrianus W.M. van der Velden, Annaiah Cariappa, Catherine Chase, Paul Russell, Michael N. Starnbach, Pandelakis A. Koni, Shiv Pillai, Wolfgang Weninger, Ulrich H. von Andrian

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184 Scopus citations

Abstract

Dendritic cells (DCs) carry antigen from peripheral tissues via lymphatics to lymph nodes. We report here that differentiated DCs can also travel from the periphery into the blood. Circulating DCs migrated to the spleen, liver and lung but not lymph nodes. They also homed to the bone marrow, where they were retained better than in most other tissues. Homing of DCs to the bone marrow depended on constitutively expressed vascular cell adhesion molecule 1 and endothelial selectins in bone marrow microvessels. Two-photon intravital microscopy in bone marrow cavities showed that DCs formed stable antigen-dependent contacts with bone marrow -resident central memory T cells. Moreover, using this previously unknown migratory pathway, antigen-pulsed DCs were able to trigger central memory T cell -mediated recall responses in the bone marrow.

Original language	English (US)
Pages (from-to)	1029-1037
Number of pages	9
Journal	Nature Immunology
Volume	6
Issue number	10
DOIs	https://doi.org/10.1038/ni1249
State	Published - Oct 2005
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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Cavanagh, L. L., Bonasio, R., Mazo, I. B., Halin, C., Cheng, G., van der Velden, A. W. M., Cariappa, A., Chase, C., Russell, P., Starnbach, M. N., Koni, P. A., Pillai, S., Weninger, W., & von Andrian, U. H. (2005). Activation of bone marrow-resident memory T cells by circulating, antigen-bearing dendritic cells. Nature Immunology, 6(10), 1029-1037. https://doi.org/10.1038/ni1249

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title = "Activation of bone marrow-resident memory T cells by circulating, antigen-bearing dendritic cells",

abstract = "Dendritic cells (DCs) carry antigen from peripheral tissues via lymphatics to lymph nodes. We report here that differentiated DCs can also travel from the periphery into the blood. Circulating DCs migrated to the spleen, liver and lung but not lymph nodes. They also homed to the bone marrow, where they were retained better than in most other tissues. Homing of DCs to the bone marrow depended on constitutively expressed vascular cell adhesion molecule 1 and endothelial selectins in bone marrow microvessels. Two-photon intravital microscopy in bone marrow cavities showed that DCs formed stable antigen-dependent contacts with bone marrow -resident central memory T cells. Moreover, using this previously unknown migratory pathway, antigen-pulsed DCs were able to trigger central memory T cell -mediated recall responses in the bone marrow.",

author = "Cavanagh, {Lois L.} and Roberto Bonasio and Mazo, {Irina B.} and Cornelia Halin and Guiying Cheng and {van der Velden}, {Adrianus W.M.} and Annaiah Cariappa and Catherine Chase and Paul Russell and Starnbach, {Michael N.} and Koni, {Pandelakis A.} and Shiv Pillai and Wolfgang Weninger and {von Andrian}, {Ulrich H.}",

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AU - Cavanagh, Lois L.

AU - Bonasio, Roberto

AU - Mazo, Irina B.

AU - Halin, Cornelia

AU - Cheng, Guiying

AU - van der Velden, Adrianus W.M.

AU - Cariappa, Annaiah

AU - Chase, Catherine

AU - Russell, Paul

AU - Starnbach, Michael N.

AU - Koni, Pandelakis A.

AU - Pillai, Shiv

AU - Weninger, Wolfgang

AU - von Andrian, Ulrich H.

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AB - Dendritic cells (DCs) carry antigen from peripheral tissues via lymphatics to lymph nodes. We report here that differentiated DCs can also travel from the periphery into the blood. Circulating DCs migrated to the spleen, liver and lung but not lymph nodes. They also homed to the bone marrow, where they were retained better than in most other tissues. Homing of DCs to the bone marrow depended on constitutively expressed vascular cell adhesion molecule 1 and endothelial selectins in bone marrow microvessels. Two-photon intravital microscopy in bone marrow cavities showed that DCs formed stable antigen-dependent contacts with bone marrow -resident central memory T cells. Moreover, using this previously unknown migratory pathway, antigen-pulsed DCs were able to trigger central memory T cell -mediated recall responses in the bone marrow.

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Activation of bone marrow-resident memory T cells by circulating, antigen-bearing dendritic cells

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