Activities of dicationic compounds against Trichomonas vaginalis

Andrea L. Crowell, Chad E. Stephens, Arvind Kumar, David W. Boykin, W. Evan Secor

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

We evaluated 44 novel cationic compounds for activity against metronidazole-sensitive and -resistant Trichomonas vaginalis isolates. Six compounds in three different structural classes demonstrated 50% inhibitory concentrations as low as 1 μM against both sensitive and resistant isolates, suggesting a mode of action independent of parasite biochemical pathways that confer resistance to 5-nitroimidazoles.

Original languageEnglish (US)
Pages (from-to)3602-3605
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume48
Issue number9
DOIs
StatePublished - Sep 1 2004
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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  • Cite this

    Crowell, A. L., Stephens, C. E., Kumar, A., Boykin, D. W., & Secor, W. E. (2004). Activities of dicationic compounds against Trichomonas vaginalis. Antimicrobial agents and chemotherapy, 48(9), 3602-3605. https://doi.org/10.1128/AAC.48.9.3602-3605.2004