Abstract
We evaluated 44 novel cationic compounds for activity against metronidazole-sensitive and -resistant Trichomonas vaginalis isolates. Six compounds in three different structural classes demonstrated 50% inhibitory concentrations as low as 1 μM against both sensitive and resistant isolates, suggesting a mode of action independent of parasite biochemical pathways that confer resistance to 5-nitroimidazoles.
Original language | English (US) |
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Pages (from-to) | 3602-3605 |
Number of pages | 4 |
Journal | Antimicrobial agents and chemotherapy |
Volume | 48 |
Issue number | 9 |
DOIs | |
State | Published - Sep 2004 |
Externally published | Yes |
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases