Activities of dicationic compounds against Trichomonas vaginalis

Andrea L. Crowell; Chad E. Stephens; Arvind Kumar; David W. Boykin; W. Evan Secor

doi:10.1128/AAC.48.9.3602-3605.2004

Activities of dicationic compounds against Trichomonas vaginalis

Andrea L. Crowell, Chad E. Stephens, Arvind Kumar, David W. Boykin, W. Evan Secor

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

We evaluated 44 novel cationic compounds for activity against metronidazole-sensitive and -resistant Trichomonas vaginalis isolates. Six compounds in three different structural classes demonstrated 50% inhibitory concentrations as low as 1 μM against both sensitive and resistant isolates, suggesting a mode of action independent of parasite biochemical pathways that confer resistance to 5-nitroimidazoles.

Original language	English (US)
Pages (from-to)	3602-3605
Number of pages	4
Journal	Antimicrobial agents and chemotherapy
Volume	48
Issue number	9
DOIs	https://doi.org/10.1128/AAC.48.9.3602-3605.2004
State	Published - Sep 2004
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/AAC.48.9.3602-3605.2004

Cite this

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abstract = "We evaluated 44 novel cationic compounds for activity against metronidazole-sensitive and -resistant Trichomonas vaginalis isolates. Six compounds in three different structural classes demonstrated 50% inhibitory concentrations as low as 1 μM against both sensitive and resistant isolates, suggesting a mode of action independent of parasite biochemical pathways that confer resistance to 5-nitroimidazoles.",

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AU - Secor, W. Evan

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AB - We evaluated 44 novel cationic compounds for activity against metronidazole-sensitive and -resistant Trichomonas vaginalis isolates. Six compounds in three different structural classes demonstrated 50% inhibitory concentrations as low as 1 μM against both sensitive and resistant isolates, suggesting a mode of action independent of parasite biochemical pathways that confer resistance to 5-nitroimidazoles.

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Activities of dicationic compounds against Trichomonas vaginalis

Abstract

ASJC Scopus subject areas

UN SDGs

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