Activities of dicationic compounds against Trichomonas vaginalis

Andrea L. Crowell, Chad E. Stephens, Arvind Kumar, David W. Boykin, W. Evan Secor

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We evaluated 44 novel cationic compounds for activity against metronidazole-sensitive and -resistant Trichomonas vaginalis isolates. Six compounds in three different structural classes demonstrated 50% inhibitory concentrations as low as 1 μM against both sensitive and resistant isolates, suggesting a mode of action independent of parasite biochemical pathways that confer resistance to 5-nitroimidazoles.

Original languageEnglish (US)
Pages (from-to)3602-3605
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume48
Issue number9
DOIs
StatePublished - Sep 1 2004
Externally publishedYes

Fingerprint

Trichomonas vaginalis
Metronidazole
Inhibitory Concentration 50
Parasites
4-nitroimidazole

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Activities of dicationic compounds against Trichomonas vaginalis. / Crowell, Andrea L.; Stephens, Chad E.; Kumar, Arvind; Boykin, David W.; Secor, W. Evan.

In: Antimicrobial Agents and Chemotherapy, Vol. 48, No. 9, 01.09.2004, p. 3602-3605.

Research output: Contribution to journalArticle

Crowell, Andrea L. ; Stephens, Chad E. ; Kumar, Arvind ; Boykin, David W. ; Secor, W. Evan. / Activities of dicationic compounds against Trichomonas vaginalis. In: Antimicrobial Agents and Chemotherapy. 2004 ; Vol. 48, No. 9. pp. 3602-3605.
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