Activity of arylsulfatase A, B-glucosidase and hexosaminidases in chorionic villi at six, eight and ten weeks' gestational age

J. V. Johnson, F. A. Hommes, P. G. McDonough, W. J. Butler

Research output: Contribution to journalArticle


Chorionic villus sampling is becoming an accepted method of prenatally diagnosing metabolic diseases. There are few published data on sampling at various gestational ages. Different investigators, using different methods of chorionic biopsy, perform the sampling at various gestational ages. Accurate interpretation of results is dependent on reliable normal values, which could differ on the basis of gestational age. The enzymatic activities of arylsulfatase A, B-glucosidase and hexosaminidases were compared in trophoblast from six-, eight- and ten-week gestations. No significant differences in activity levels were detected. This finding confirms the accuracy of metabolic diagnosis for these enzyme-deficiency syndromes in trophoblastic tissue at gestational ages of six to ten weeks without a requirement for gestational-age-specific normal values.

Original languageEnglish (US)
Pages (from-to)219-222
Number of pages4
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Issue number2
Publication statusPublished - Jan 1 1988


ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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