Activity of arylsulfatase A, B-glucosidase and hexosaminidases in chorionic villi at six, eight and ten weeks' gestational age

J. V. Johnson, F. A. Hommes, P. G. McDonough, W. J. Butler

Research output: Contribution to journalArticle

Abstract

Chorionic villus sampling is becoming an accepted method of prenatally diagnosing metabolic diseases. There are few published data on sampling at various gestational ages. Different investigators, using different methods of chorionic biopsy, perform the sampling at various gestational ages. Accurate interpretation of results is dependent on reliable normal values, which could differ on the basis of gestational age. The enzymatic activities of arylsulfatase A, B-glucosidase and hexosaminidases were compared in trophoblast from six-, eight- and ten-week gestations. No significant differences in activity levels were detected. This finding confirms the accuracy of metabolic diagnosis for these enzyme-deficiency syndromes in trophoblastic tissue at gestational ages of six to ten weeks without a requirement for gestational-age-specific normal values.

Original languageEnglish (US)
Pages (from-to)219-222
Number of pages4
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume33
Issue number2
StatePublished - 1988

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'Activity of arylsulfatase A, B-glucosidase and hexosaminidases in chorionic villi at six, eight and ten weeks' gestational age'. Together they form a unique fingerprint.

  • Cite this