Activity of some Mannich bases of conjugated styryl ketones against Candida albicans

J. R. Dimmock, P. Kumar, Elias Kurian Manavathu, N. Obedeanu, J. Grewal

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

A number of Mannich bases of conjugated styryl ketones displayed activity against Candida albicans strains 3153A and B311. Antifungal potency was influenced by the relative hydrophobicities of the molecules and on occasions by the electronic nature of the aryl substituents. The compounds inhibited one or more of the following enzymes in the glutathione metabolic pathway namely glutathione S-transferases, glutathione reductase, γ-glutamyl transpeptidase and glutathione peroxidase. Nearly half of the compounds examined on the yeast-to-mycelium transition in C. albicans 3153A prevented this conversion from occuring.

Original languageEnglish (US)
Pages (from-to)909-912
Number of pages4
JournalPharmazie
Volume49
Issue number12
StatePublished - Jan 1 1994

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Mannich Bases
Ketones
Candida albicans
gamma-Glutamyltransferase
Glutathione Reductase
Mycelium
Glutathione Peroxidase
Metabolic Networks and Pathways
Glutathione Transferase
Hydrophobic and Hydrophilic Interactions
Glutathione
Yeasts
Enzymes

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Dimmock, J. R., Kumar, P., Manavathu, E. K., Obedeanu, N., & Grewal, J. (1994). Activity of some Mannich bases of conjugated styryl ketones against Candida albicans. Pharmazie, 49(12), 909-912.

Activity of some Mannich bases of conjugated styryl ketones against Candida albicans. / Dimmock, J. R.; Kumar, P.; Manavathu, Elias Kurian; Obedeanu, N.; Grewal, J.

In: Pharmazie, Vol. 49, No. 12, 01.01.1994, p. 909-912.

Research output: Contribution to journalArticle

Dimmock, JR, Kumar, P, Manavathu, EK, Obedeanu, N & Grewal, J 1994, 'Activity of some Mannich bases of conjugated styryl ketones against Candida albicans', Pharmazie, vol. 49, no. 12, pp. 909-912.
Dimmock JR, Kumar P, Manavathu EK, Obedeanu N, Grewal J. Activity of some Mannich bases of conjugated styryl ketones against Candida albicans. Pharmazie. 1994 Jan 1;49(12):909-912.
Dimmock, J. R. ; Kumar, P. ; Manavathu, Elias Kurian ; Obedeanu, N. ; Grewal, J. / Activity of some Mannich bases of conjugated styryl ketones against Candida albicans. In: Pharmazie. 1994 ; Vol. 49, No. 12. pp. 909-912.
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