TY - JOUR
T1 - Acute aerobic exercise differentially alters acylated ghrelin and perceived fullness in normal-weight and obese individuals
AU - Heden, Timothy D.
AU - Liu, Ying
AU - Park, Youngmin
AU - Dellsperger, Kevin C
AU - Kanaley, Jill A.
PY - 2013/9/1
Y1 - 2013/9/1
N2 - Heden TD, Liu Y, Park Y, Dellsperger KC, Kanaley JA. Acute aerobic exercise differentially alters acylated ghrelin and perceived fullness in normal-weight and obese individuals. J Appl Physiol 115: 680-687, 2013. First published July 11, 2013; doi:10.1152/japplphysiol.00515.2013.-Adiposity alters acylated ghrelin concentrations, but it is unknown whether adiposity alters the effect of exercise and feeding on acylated ghrelin responses. Therefore, the purpose of this study was to determine whether adiposity [normal-weight (NW) vs. obese (Ob)] influences the effect of exercise and feeding on acylated ghrelin, hunger, and fullness. Fourteen NW and 14 Ob individuals completed two trials in a randomized counterbalanced fashion, including a prior exercise trial (EX) and a no exercise trial (NoEX). During the EX trial, the participants performed 1 h of treadmill walking (55-60% peak O2 uptake) during the evening, 12 h before a 4-h standardized mixed meal test. Frequent blood samples were taken and analyzed for acylated ghrelin, and a visual analog scale was used to assess perceived hunger and fullness. In NW individuals, EX, compared with NoEX, reduced fasting acylated ghrelin concentrations by 18% (P = 0.03), and, in response to feeding, the change in acylated ghrelin (P = 0.02) was attenuated by 39%, but perceived hunger and fullness were unaltered. In Ob individuals, despite no changes in fasting or postprandial acylated ghrelin concentrations with EX, postprandial fullness was attenuated by 46% compared with NoEX (P = 0.05). In summary, exercise performed the night before a meal suppresses acylated ghrelin concentrations in NW individuals without altering perceived hunger or fullness. In Ob individuals, despite no changes in acylated ghrelin concentrations, EX reduced the fullness response to the test meal. Acylated ghrelin and perceived fullness responses are differently altered by acute aerobic exercise in NW and Ob individuals.
AB - Heden TD, Liu Y, Park Y, Dellsperger KC, Kanaley JA. Acute aerobic exercise differentially alters acylated ghrelin and perceived fullness in normal-weight and obese individuals. J Appl Physiol 115: 680-687, 2013. First published July 11, 2013; doi:10.1152/japplphysiol.00515.2013.-Adiposity alters acylated ghrelin concentrations, but it is unknown whether adiposity alters the effect of exercise and feeding on acylated ghrelin responses. Therefore, the purpose of this study was to determine whether adiposity [normal-weight (NW) vs. obese (Ob)] influences the effect of exercise and feeding on acylated ghrelin, hunger, and fullness. Fourteen NW and 14 Ob individuals completed two trials in a randomized counterbalanced fashion, including a prior exercise trial (EX) and a no exercise trial (NoEX). During the EX trial, the participants performed 1 h of treadmill walking (55-60% peak O2 uptake) during the evening, 12 h before a 4-h standardized mixed meal test. Frequent blood samples were taken and analyzed for acylated ghrelin, and a visual analog scale was used to assess perceived hunger and fullness. In NW individuals, EX, compared with NoEX, reduced fasting acylated ghrelin concentrations by 18% (P = 0.03), and, in response to feeding, the change in acylated ghrelin (P = 0.02) was attenuated by 39%, but perceived hunger and fullness were unaltered. In Ob individuals, despite no changes in fasting or postprandial acylated ghrelin concentrations with EX, postprandial fullness was attenuated by 46% compared with NoEX (P = 0.05). In summary, exercise performed the night before a meal suppresses acylated ghrelin concentrations in NW individuals without altering perceived hunger or fullness. In Ob individuals, despite no changes in acylated ghrelin concentrations, EX reduced the fullness response to the test meal. Acylated ghrelin and perceived fullness responses are differently altered by acute aerobic exercise in NW and Ob individuals.
KW - Fullness
KW - Gut hormone
KW - Hunger
KW - Walking
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U2 - 10.1152/japplphysiol.00515.2013
DO - 10.1152/japplphysiol.00515.2013
M3 - Article
C2 - 23845979
AN - SCOPUS:84883585241
SN - 8750-7587
VL - 115
SP - 680
EP - 687
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
IS - 5
ER -