Acute effects of phenytoin on peripheral nerve function in the rat

Donald J. Marcus, Thomas R. Swift, Thomas F. McDonald

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


The acute effect of intraperitoneal injection of phenytoin on rat peripheral nerve was studied. Conduction velocities in the ventral caudal nerve were measured hourly and phenytoin blood levels were obtained 4 to 5 hours after injection. Conduction velocity decreased by 23% in the 25 phenytoin‐treated animals from a control value of 30.0 ± 1.3 m/sec (mean ± SEM) to a 4‐hour value of 23.0 ± 1.3 m/sec (P < 0.001). The phenytoin blood level 4 hours after injection was 45.0 ± 1.3 μg/ml. Amplitudes of evoked muscle action potentials in the treated group decreased by 37% from control values. High levels of phenytoin induce prompt slowing of nerve conduction velocity within hours, which may be mediated by mechanisms similar to those responsible for toxic central effects.

Original languageEnglish (US)
Pages (from-to)48-50
Number of pages3
JournalMuscle & Nerve
Issue number1
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

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