Acute graft-versus-host disease of the lung after liver transplantation.

Kenneth S Knox, Mehrdad Behnia, Lisa R Smith, Gail H Vance, Michael Busk, Oscar W Cummings, Paul Y Kwo, David S Wilkes

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We describe the first case of a man who developed acute graft-versus-host disease (GVHD), isolated to the lung, after an orthotopic liver transplant from a female donor. Our patient experienced dyspnea, worsening hypoxemia, and a progressive obstructive ventilatory defect 12 days after liver transplantation. Open-lung biopsy revealed grade 2 lymphocytic bronchiolitis, the pathologic and immunologic correlate of acute pulmonary GVHD. Fluorescent in situ hybridization confirmed donor cells at sites of peribronchiolar inflammation. High-dose corticosteroids were given with a return to baseline pulmonary function. The current case should alert clinicians to investigate pulmonary GVHD as a potential cause of postoperative dyspnea in liver transplant recipients.;
Original languageUndefined
Pages (from-to)968 - 971
JournalLiver Transplantation
Volume8
Issue number10
StatePublished - 2002

Keywords

  • Graft vs Host Disease/*etiology, Liver Transplantation/*adverse effects, Lung Diseases/*etiology, Acute Disease, Administration, Oral, Aged, Bronchitis/etiology, Bronchitis/pathology, Drug Administration Schedule, Female, Glucocorticoids/administration & dosage, Glucocorticoids/therapeutic use, Graft vs Host Disease/complications, Graft vs Host Disease/drug therapy, Humans, Injections, Intravenous, Lung Diseases/complications, Lung Diseases/drug therapy, Lymphocytes/pathology, Male, Methylprednisolone/administration & dosage, Methylprednisolone/therapeutic use, Prednisone/administration & dosage, Prednisone/therapeutic use, Treatment Outcome

Cite this

Knox, K. S., Behnia, M., Smith, L. R., Vance, G. H., Busk, M., Cummings, O. W., ... Wilkes, D. S. (2002). Acute graft-versus-host disease of the lung after liver transplantation. Liver Transplantation, 8(10), 968 - 971.

Acute graft-versus-host disease of the lung after liver transplantation. / Knox, Kenneth S; Behnia, Mehrdad; Smith, Lisa R; Vance, Gail H; Busk, Michael; Cummings, Oscar W; Kwo, Paul Y; Wilkes, David S.

In: Liver Transplantation, Vol. 8, No. 10, 2002, p. 968 - 971.

Research output: Contribution to journalArticle

Knox, KS, Behnia, M, Smith, LR, Vance, GH, Busk, M, Cummings, OW, Kwo, PY & Wilkes, DS 2002, 'Acute graft-versus-host disease of the lung after liver transplantation.', Liver Transplantation, vol. 8, no. 10, pp. 968 - 971.
Knox KS, Behnia M, Smith LR, Vance GH, Busk M, Cummings OW et al. Acute graft-versus-host disease of the lung after liver transplantation. Liver Transplantation. 2002;8(10):968 - 971.
Knox, Kenneth S ; Behnia, Mehrdad ; Smith, Lisa R ; Vance, Gail H ; Busk, Michael ; Cummings, Oscar W ; Kwo, Paul Y ; Wilkes, David S. / Acute graft-versus-host disease of the lung after liver transplantation. In: Liver Transplantation. 2002 ; Vol. 8, No. 10. pp. 968 - 971.
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