Acute oral toxicity of sodium fluoride and monofluorophosphate separately or incombination in rats

Gary M. Whitford, N. L. Birdsong-Whitford, C. Finidori

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Fasted Sprague-Dawley male rats were used in three experiments to determine the acute LD50 values of fluoridewhen it was administered intragastrically as NaF, disodium monofluorophosphate (Na2P03F, MFP) orNaF and MFP. Another study was done to examine the relationship between the likelihood of a fatal outcome and peak plasma fluoride concentrations as well as 6-hour AUC values. It was concluded that fatalities due to the acute toxic effects of fluoride were:(1) independent of the chemical form in which it was given; (2) independent of the vehicle (dentifrice or water), and (3) not predictable in terms of a well-defined threshold range of peak plasma fluoride concentrations or AUC values.

Original languageEnglish (US)
Pages (from-to)121-126
Number of pages6
JournalCaries Research
Volume24
Issue number2
DOIs
StatePublished - Jan 1 1990

Fingerprint

fluorophosphate
Sodium Fluoride
Fluorides
Area Under Curve
Dentifrices
Fatal Outcome
Poisons
Lethal Dose 50
Sprague Dawley Rats
Water

Keywords

  • Absorption
  • Acute toxicity
  • Bioavailability
  • Dentifrice
  • LD<inf>50</inf>
  • Plasma concentration

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Acute oral toxicity of sodium fluoride and monofluorophosphate separately or incombination in rats. / Whitford, Gary M.; Birdsong-Whitford, N. L.; Finidori, C.

In: Caries Research, Vol. 24, No. 2, 01.01.1990, p. 121-126.

Research output: Contribution to journalArticle

Whitford, Gary M. ; Birdsong-Whitford, N. L. ; Finidori, C. / Acute oral toxicity of sodium fluoride and monofluorophosphate separately or incombination in rats. In: Caries Research. 1990 ; Vol. 24, No. 2. pp. 121-126.
@article{5e3ae922900840da8672d9d00a9c3c09,
title = "Acute oral toxicity of sodium fluoride and monofluorophosphate separately or incombination in rats",
abstract = "Fasted Sprague-Dawley male rats were used in three experiments to determine the acute LD50 values of fluoridewhen it was administered intragastrically as NaF, disodium monofluorophosphate (Na2P03F, MFP) orNaF and MFP. Another study was done to examine the relationship between the likelihood of a fatal outcome and peak plasma fluoride concentrations as well as 6-hour AUC values. It was concluded that fatalities due to the acute toxic effects of fluoride were:(1) independent of the chemical form in which it was given; (2) independent of the vehicle (dentifrice or water), and (3) not predictable in terms of a well-defined threshold range of peak plasma fluoride concentrations or AUC values.",
keywords = "Absorption, Acute toxicity, Bioavailability, Dentifrice, LD<inf>50</inf>, Plasma concentration",
author = "Whitford, {Gary M.} and Birdsong-Whitford, {N. L.} and C. Finidori",
year = "1990",
month = "1",
day = "1",
doi = "10.1159/000261252",
language = "English (US)",
volume = "24",
pages = "121--126",
journal = "Caries Research",
issn = "0008-6568",
publisher = "S. Karger AG",
number = "2",

}

TY - JOUR

T1 - Acute oral toxicity of sodium fluoride and monofluorophosphate separately or incombination in rats

AU - Whitford, Gary M.

AU - Birdsong-Whitford, N. L.

AU - Finidori, C.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - Fasted Sprague-Dawley male rats were used in three experiments to determine the acute LD50 values of fluoridewhen it was administered intragastrically as NaF, disodium monofluorophosphate (Na2P03F, MFP) orNaF and MFP. Another study was done to examine the relationship between the likelihood of a fatal outcome and peak plasma fluoride concentrations as well as 6-hour AUC values. It was concluded that fatalities due to the acute toxic effects of fluoride were:(1) independent of the chemical form in which it was given; (2) independent of the vehicle (dentifrice or water), and (3) not predictable in terms of a well-defined threshold range of peak plasma fluoride concentrations or AUC values.

AB - Fasted Sprague-Dawley male rats were used in three experiments to determine the acute LD50 values of fluoridewhen it was administered intragastrically as NaF, disodium monofluorophosphate (Na2P03F, MFP) orNaF and MFP. Another study was done to examine the relationship between the likelihood of a fatal outcome and peak plasma fluoride concentrations as well as 6-hour AUC values. It was concluded that fatalities due to the acute toxic effects of fluoride were:(1) independent of the chemical form in which it was given; (2) independent of the vehicle (dentifrice or water), and (3) not predictable in terms of a well-defined threshold range of peak plasma fluoride concentrations or AUC values.

KW - Absorption

KW - Acute toxicity

KW - Bioavailability

KW - Dentifrice

KW - LD<inf>50</inf>

KW - Plasma concentration

UR - http://www.scopus.com/inward/record.url?scp=0025230547&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025230547&partnerID=8YFLogxK

U2 - 10.1159/000261252

DO - 10.1159/000261252

M3 - Article

VL - 24

SP - 121

EP - 126

JO - Caries Research

JF - Caries Research

SN - 0008-6568

IS - 2

ER -