Acute oral toxicity of sodium fluoride and monofluorophosphate separately or incombination in rats

Gary M. Whitford, N. L. Birdsong-Whitford, C. Finidori

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Fasted Sprague-Dawley male rats were used in three experiments to determine the acute LD50 values of fluoridewhen it was administered intragastrically as NaF, disodium monofluorophosphate (Na2P03F, MFP) orNaF and MFP. Another study was done to examine the relationship between the likelihood of a fatal outcome and peak plasma fluoride concentrations as well as 6-hour AUC values. It was concluded that fatalities due to the acute toxic effects of fluoride were:(1) independent of the chemical form in which it was given; (2) independent of the vehicle (dentifrice or water), and (3) not predictable in terms of a well-defined threshold range of peak plasma fluoride concentrations or AUC values.

Original languageEnglish (US)
Pages (from-to)121-126
Number of pages6
JournalCaries Research
Volume24
Issue number2
DOIs
StatePublished - Jan 1 1990

Keywords

  • Absorption
  • Acute toxicity
  • Bioavailability
  • Dentifrice
  • LD<inf>50</inf>
  • Plasma concentration

ASJC Scopus subject areas

  • Dentistry(all)

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