Acute splenic complications and implications of splenectomy in hemoglobin SC disease

Karthi Subbannan, Celalettin Ustun, Kavita Natarajan, Betsy Clair, Lisa Daitch, Sabine Fields, Ferdane Kutlar, Abdullah Kutlar

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Splenectomy indications and outcome were evaluated in 124 adults with hemoglobin SC disease (Hb SC). Twelve patients (9.6%) required splenectomy. There was a significant difference between the splenectomy group and the non-splenectomy group, respectively, regarding Hb levels (median 7.2 gdL vs. 12.5 gdL, P < 0.0001), platelet counts (median 146 × 106L vs. 275 × 106L, P = 0.031), palpable spleen rate (66% vs. 16%, P = 0.0003%), acute chest syndrome frequency (75% vs. 12%P = 0.0004) and cholecystectomy rate (66% vs. 13%, P = 0.0004). No significant morbidity or mortality occurred postsplenectomy. There is a subgroup of Hb SC patients requiring splenectomy, in which splenectomy is effective. Although it appears to be safe regarding short-term complications of surgery, long-term adverse effects such as infections have to be evaluated cautiously.

Original languageEnglish (US)
Pages (from-to)258-260
Number of pages3
JournalEuropean Journal of Haematology
Volume83
Issue number3
DOIs
StatePublished - Sep 1 2009

Keywords

  • Hemoglobin SC disease
  • Splenectomy
  • Splenic hemorrhage
  • Splenic infarct

ASJC Scopus subject areas

  • Hematology

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