Adrenal function during childhood and puberty in daughters of women with polycystic ovary syndrome

Manuel Maliqueo, Teresa Sir-Petermann, Virginia Pérez, Bárbara Echiburú, Amanda Ladrón De Guevara, Carla Gálvez, Nicolás Crisosto, Ricardo Azziz

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Context: In some patients, PCOS may develop as a consequence of an exaggerated adrenarche during pubertal development. Objective: The aim of the study was to assess adrenal function during childhood and pubertal development in daughters of women with PCOS (PCOSd). Design: We included 98 PCOSd [64 during childhood (ages 4-8 yr) and 34 during the peripubertal period (ages 9-13 yr)] and 51 daughters of controlwomen(Cd) [30 during childhood and 21 during the peripubertal period]. In both groups, an acute ACTH-(1-24) stimulation test (0.25 mg) and an oral glucose tolerance test were performed. Bone age and serum concentrations of cortisol, androstenedione, 17-hydroxyprogesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), glucose, and insulin were determined. Results: PCOSd and Cd were similar in age and body mass index. During the peripubertal period, basal and poststimulated DHEAS concentrations were higher in PCOSd compared to Cd. Among PCOSd, 12.5% of girls in childhood and 32.4% in peripuberty presented biochemical evidence of exaggerated adrenarche. Stimulated insulin was higher in PCOSd compared to Cd during childhood (P = 0.03) and peripuberty (P = 0.03). An advancement of 8 months between bone and chronological age was observed in peripubertal PCOSd compared to Cd. Conclusions: In PCOSd, basal and stimulated DHEAS concentrations were higher during the onset of puberty. Around 30% of the PCOSd demonstrated an exacerbated adrenarche, which may reflect increased P450c17 activity. In addition, a modest advance in bone age was observed, probably secondary to the hyperinsulinemia and/or adrenal hyperandrogenism.

Original languageEnglish (US)
Pages (from-to)3282-3288
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume94
Issue number9
DOIs
StatePublished - Sep 2009

Fingerprint

Adrenarche
Dehydroepiandrosterone Sulfate
Polycystic Ovary Syndrome
Puberty
Nuclear Family
Bone
Bone and Bones
Insulin
Cosyntropin
17-alpha-Hydroxyprogesterone
Hyperandrogenism
Glucose
Dehydroepiandrosterone
Androstenedione
Hyperinsulinism
Glucose Tolerance Test
Hydrocortisone
Body Mass Index
Serum

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Maliqueo, M., Sir-Petermann, T., Pérez, V., Echiburú, B., De Guevara, A. L., Gálvez, C., ... Azziz, R. (2009). Adrenal function during childhood and puberty in daughters of women with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism, 94(9), 3282-3288. https://doi.org/10.1210/jc.2009-0427

Adrenal function during childhood and puberty in daughters of women with polycystic ovary syndrome. / Maliqueo, Manuel; Sir-Petermann, Teresa; Pérez, Virginia; Echiburú, Bárbara; De Guevara, Amanda Ladrón; Gálvez, Carla; Crisosto, Nicolás; Azziz, Ricardo.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 94, No. 9, 09.2009, p. 3282-3288.

Research output: Contribution to journalArticle

Maliqueo, M, Sir-Petermann, T, Pérez, V, Echiburú, B, De Guevara, AL, Gálvez, C, Crisosto, N & Azziz, R 2009, 'Adrenal function during childhood and puberty in daughters of women with polycystic ovary syndrome', Journal of Clinical Endocrinology and Metabolism, vol. 94, no. 9, pp. 3282-3288. https://doi.org/10.1210/jc.2009-0427
Maliqueo, Manuel ; Sir-Petermann, Teresa ; Pérez, Virginia ; Echiburú, Bárbara ; De Guevara, Amanda Ladrón ; Gálvez, Carla ; Crisosto, Nicolás ; Azziz, Ricardo. / Adrenal function during childhood and puberty in daughters of women with polycystic ovary syndrome. In: Journal of Clinical Endocrinology and Metabolism. 2009 ; Vol. 94, No. 9. pp. 3282-3288.
@article{d838ce54badd4e419fa1d42fbf03b7cb,
title = "Adrenal function during childhood and puberty in daughters of women with polycystic ovary syndrome",
abstract = "Context: In some patients, PCOS may develop as a consequence of an exaggerated adrenarche during pubertal development. Objective: The aim of the study was to assess adrenal function during childhood and pubertal development in daughters of women with PCOS (PCOSd). Design: We included 98 PCOSd [64 during childhood (ages 4-8 yr) and 34 during the peripubertal period (ages 9-13 yr)] and 51 daughters of controlwomen(Cd) [30 during childhood and 21 during the peripubertal period]. In both groups, an acute ACTH-(1-24) stimulation test (0.25 mg) and an oral glucose tolerance test were performed. Bone age and serum concentrations of cortisol, androstenedione, 17-hydroxyprogesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), glucose, and insulin were determined. Results: PCOSd and Cd were similar in age and body mass index. During the peripubertal period, basal and poststimulated DHEAS concentrations were higher in PCOSd compared to Cd. Among PCOSd, 12.5{\%} of girls in childhood and 32.4{\%} in peripuberty presented biochemical evidence of exaggerated adrenarche. Stimulated insulin was higher in PCOSd compared to Cd during childhood (P = 0.03) and peripuberty (P = 0.03). An advancement of 8 months between bone and chronological age was observed in peripubertal PCOSd compared to Cd. Conclusions: In PCOSd, basal and stimulated DHEAS concentrations were higher during the onset of puberty. Around 30{\%} of the PCOSd demonstrated an exacerbated adrenarche, which may reflect increased P450c17 activity. In addition, a modest advance in bone age was observed, probably secondary to the hyperinsulinemia and/or adrenal hyperandrogenism.",
author = "Manuel Maliqueo and Teresa Sir-Petermann and Virginia P{\'e}rez and B{\'a}rbara Echibur{\'u} and {De Guevara}, {Amanda Ladr{\'o}n} and Carla G{\'a}lvez and Nicol{\'a}s Crisosto and Ricardo Azziz",
year = "2009",
month = "9",
doi = "10.1210/jc.2009-0427",
language = "English (US)",
volume = "94",
pages = "3282--3288",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "9",

}

TY - JOUR

T1 - Adrenal function during childhood and puberty in daughters of women with polycystic ovary syndrome

AU - Maliqueo, Manuel

AU - Sir-Petermann, Teresa

AU - Pérez, Virginia

AU - Echiburú, Bárbara

AU - De Guevara, Amanda Ladrón

AU - Gálvez, Carla

AU - Crisosto, Nicolás

AU - Azziz, Ricardo

PY - 2009/9

Y1 - 2009/9

N2 - Context: In some patients, PCOS may develop as a consequence of an exaggerated adrenarche during pubertal development. Objective: The aim of the study was to assess adrenal function during childhood and pubertal development in daughters of women with PCOS (PCOSd). Design: We included 98 PCOSd [64 during childhood (ages 4-8 yr) and 34 during the peripubertal period (ages 9-13 yr)] and 51 daughters of controlwomen(Cd) [30 during childhood and 21 during the peripubertal period]. In both groups, an acute ACTH-(1-24) stimulation test (0.25 mg) and an oral glucose tolerance test were performed. Bone age and serum concentrations of cortisol, androstenedione, 17-hydroxyprogesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), glucose, and insulin were determined. Results: PCOSd and Cd were similar in age and body mass index. During the peripubertal period, basal and poststimulated DHEAS concentrations were higher in PCOSd compared to Cd. Among PCOSd, 12.5% of girls in childhood and 32.4% in peripuberty presented biochemical evidence of exaggerated adrenarche. Stimulated insulin was higher in PCOSd compared to Cd during childhood (P = 0.03) and peripuberty (P = 0.03). An advancement of 8 months between bone and chronological age was observed in peripubertal PCOSd compared to Cd. Conclusions: In PCOSd, basal and stimulated DHEAS concentrations were higher during the onset of puberty. Around 30% of the PCOSd demonstrated an exacerbated adrenarche, which may reflect increased P450c17 activity. In addition, a modest advance in bone age was observed, probably secondary to the hyperinsulinemia and/or adrenal hyperandrogenism.

AB - Context: In some patients, PCOS may develop as a consequence of an exaggerated adrenarche during pubertal development. Objective: The aim of the study was to assess adrenal function during childhood and pubertal development in daughters of women with PCOS (PCOSd). Design: We included 98 PCOSd [64 during childhood (ages 4-8 yr) and 34 during the peripubertal period (ages 9-13 yr)] and 51 daughters of controlwomen(Cd) [30 during childhood and 21 during the peripubertal period]. In both groups, an acute ACTH-(1-24) stimulation test (0.25 mg) and an oral glucose tolerance test were performed. Bone age and serum concentrations of cortisol, androstenedione, 17-hydroxyprogesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), glucose, and insulin were determined. Results: PCOSd and Cd were similar in age and body mass index. During the peripubertal period, basal and poststimulated DHEAS concentrations were higher in PCOSd compared to Cd. Among PCOSd, 12.5% of girls in childhood and 32.4% in peripuberty presented biochemical evidence of exaggerated adrenarche. Stimulated insulin was higher in PCOSd compared to Cd during childhood (P = 0.03) and peripuberty (P = 0.03). An advancement of 8 months between bone and chronological age was observed in peripubertal PCOSd compared to Cd. Conclusions: In PCOSd, basal and stimulated DHEAS concentrations were higher during the onset of puberty. Around 30% of the PCOSd demonstrated an exacerbated adrenarche, which may reflect increased P450c17 activity. In addition, a modest advance in bone age was observed, probably secondary to the hyperinsulinemia and/or adrenal hyperandrogenism.

UR - http://www.scopus.com/inward/record.url?scp=69949102339&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=69949102339&partnerID=8YFLogxK

U2 - 10.1210/jc.2009-0427

DO - 10.1210/jc.2009-0427

M3 - Article

C2 - 19567527

AN - SCOPUS:69949102339

VL - 94

SP - 3282

EP - 3288

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 9

ER -