Advances in Antimicrobial Microneedle Patches for Combating Infections

Rezvan Jamaledin, Cynthia K.Y. Yiu, Ehsan N. Zare, Li Na Niu, Raffaele Vecchione, Guojun Chen, Zhen Gu, Franklin R. Tay, Pooyan Makvandi

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Skin infections caused by bacteria, viruses and fungi are difficult to treat by conventional topical administration because of poor drug penetration across the stratum corneum. This results in low bioavailability of drugs to the infection site, as well as the lack of prolonged release. Emerging antimicrobial transdermal and ocular microneedle patches have become promising medical devices for the delivery of various antibacterial, antifungal, and antiviral therapeutics. In the present review, skin anatomy and its barriers along with skin infection are discussed. Potential strategies for designing antimicrobial microneedles and their targeted therapy are outlined. Finally, biosensing microneedle patches associated with personalized drug therapy and selective toxicity toward specific microbial species are discussed.

Original languageEnglish (US)
JournalAdvanced Materials
DOIs
StateAccepted/In press - 2020

Keywords

  • antibacterial microneedles
  • antifungal patches
  • antiviral microneedles
  • ocular microneedle patches
  • transdermal drug delivery
  • transdermal microneedle patches

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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  • Cite this

    Jamaledin, R., Yiu, C. K. Y., Zare, E. N., Niu, L. N., Vecchione, R., Chen, G., Gu, Z., Tay, F. R., & Makvandi, P. (Accepted/In press). Advances in Antimicrobial Microneedle Patches for Combating Infections. Advanced Materials. https://doi.org/10.1002/adma.202002129