Agents targeting c-Jun N-terminal kinase pathway as potential neuroprotectants

Guang Yi Zhang, Quan Guang Zhang

Research output: Contribution to journalReview article

30 Scopus citations

Abstract

c-Jun N-terminal kinase (JNK) plays an integral role in neuronal death in multiple cell lines following a wide variety of stimuli and in a number of physiological functions that may be involved in human disease, including CNS diseases. In the past decades, many researchers in this field have found and reinforced the concept that prolonged activation of JNK signalling can induce neuronal cell death by both a transcriptional induction of death-promoting genes and modulation of the mitochondrial apoptosis pathways. Data are emerging to extend the understanding of the JNK signalling and confirm the possibility that targeting JNK signalling may offer an effective therapy for pathological conditions in the near future. This review will focus on the pro-apoptotic role of JNK signalling and updated pharmacological inhibitors of this pathway.

Original languageEnglish (US)
Pages (from-to)1373-1383
Number of pages11
JournalExpert Opinion on Investigational Drugs
Volume14
Issue number11
DOIs
StatePublished - Nov 1 2005
Externally publishedYes

Keywords

  • Agents
  • Mixed lineage kinase
  • Neuroprotection
  • c-Jun N-terminal kinase

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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