Aging and dietary modulation of elastase and interleukin-1β secretion

J. G. Cannon, M. A. Fiatarone, M. Meydani, J. Gong, L. Scott, J. B. Blumberg, W. J. Evans

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Aging is associated with diminished immune function that may stem from alterations in arachidonic acid metabolism and lipid peroxidation. This study sought to determine if dietary modification of fatty acids influenced neutrophil and monocyte secretion after an in vivo inflammatory stress in older human subjects. Volunteers participated in protocols that forced their quadriceps muscles to lengthen during tension development (eccentric stress). These protocols can cause inflammatory foci in the muscle as well as alterations in circulating leukocyte function. In this study, in vivo neutrophil degranulation was assessed by plasma elastase concentrations, and mononuclear cell function was assessed by interleukin-1β (IL-1β) secretion in vitro. In response to eccentric stress, older subjects (>60 yr old) taking a placebo had no apparent elastase response, whereas those taking fish oil supplements responded with a 142% increase in plasma elastase (P = 0.011), similar to responses of younger reference subjects (<33 yr old) taking no supplement. Overall, elastase responses correlated with individual plasma arachidonic acid-to-eicosapentaenoic acid ratios (r = -0.881, P = 0.004). Thus apparent age-related differences in elastase release were reconciled by individual differences in fatty acid nutriture. No significant temporal changes in urinary lipid peroxide excretion or IL-1β secretion were observed; however, age-associated differences were found.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume268
Issue number1 37-1
StatePublished - Feb 13 1995

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Pancreatic Elastase
Interleukin-1
Arachidonic Acid
Neutrophils
Fatty Acids
Diet Therapy
Eicosapentaenoic Acid
Fish Oils
Lipid Peroxides
Quadriceps Muscle
Individuality
Lipid Peroxidation
Monocytes
Volunteers
Leukocytes
Placebos
Muscles

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Cannon, J. G., Fiatarone, M. A., Meydani, M., Gong, J., Scott, L., Blumberg, J. B., & Evans, W. J. (1995). Aging and dietary modulation of elastase and interleukin-1β secretion. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 268(1 37-1).

Aging and dietary modulation of elastase and interleukin-1β secretion. / Cannon, J. G.; Fiatarone, M. A.; Meydani, M.; Gong, J.; Scott, L.; Blumberg, J. B.; Evans, W. J.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 268, No. 1 37-1, 13.02.1995.

Research output: Contribution to journalArticle

Cannon, JG, Fiatarone, MA, Meydani, M, Gong, J, Scott, L, Blumberg, JB & Evans, WJ 1995, 'Aging and dietary modulation of elastase and interleukin-1β secretion', American Journal of Physiology - Regulatory Integrative and Comparative Physiology, vol. 268, no. 1 37-1.
Cannon, J. G. ; Fiatarone, M. A. ; Meydani, M. ; Gong, J. ; Scott, L. ; Blumberg, J. B. ; Evans, W. J. / Aging and dietary modulation of elastase and interleukin-1β secretion. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 1995 ; Vol. 268, No. 1 37-1.
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