Aging impairs amygdala-hippocampus interactions involved in hippocampal LTP

William Almaguer, Bárbara Estupiñán, Julietta Uta Frey, Jorge A. Bergado

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Aging impairs amygdala-hippocampus interactions involved in hippocampal LTP. NEUROBIOL. AGING. We have recently shown that the stimulation of the basolateral nucleus of the amygdala (BLA) is able to prolong early-LTP (<4h) into late-LTP (>4h) in the dentate gyrus. To study whether aging affects this interaction, aged (24-27 months) rats were used, classified as cognitively impaired (I), or non-impaired (N) by means of their results in the Morris water maze. Paired pulses (30-90 ms interval) showed no differences among age groups. Among young controls, the early-LTP induced in the dentate gyrus by stimulation of the perforant path (PP) was prolonged in a late-LTP when the BLA was stimulated 15 min later. In aged-impaired rats the stimulation of the PP induced a reduced LTP, decaying to baseline in less than 2 h. BLA stimulation was without effect. Aged non-impaired rats showed an early-LTP identical to that of young animals; however, stimulation of the BLA showed no effect. These results suggest that deficient synaptic plasticity and memory functions in aged animals might be caused, in part by impaired mechanisms of heterosynaptic reinforcement.

Original languageEnglish (US)
Pages (from-to)319-324
Number of pages6
JournalNeurobiology of Aging
Volume23
Issue number2
DOIs
StatePublished - Feb 21 2002

Keywords

  • Aging
  • Amygdala
  • Cognition
  • Emotion
  • Hippocampus
  • Long-term potentiation
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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