Agrin to YAP in Cancer and Neuromuscular Junctions

Wen Cheng Xiong, Lin Mei

Research output: Contribution to journalShort surveypeer-review

10 Scopus citations

Abstract

Agrin is utilized by motor neurons to stimulate the LRP4-MuSK receptor in muscles for neuromuscular junction (NMJ) formation. Recent studies of cancer have identified novel functions of the low-density lipoprotein receptor-related protein 4–muscle-specific kinase (LRP4–MuSK) pathway. Agrin may act as a mechanotransduction signal in the extracellular matrix (ECM) to coordinate the cross-talk between the LRP4–MuSK pathway and integrin-focal adhesion pathway. Ensuing Yes-associated protein (YAP) activation promotes hepatocellular carcinoma (HCC). Here, we discuss the implications of the converged pathways in NMJ formation and liver cancer.

Original languageEnglish (US)
Pages (from-to)247-248
Number of pages2
JournalTrends in Cancer
Volume3
Issue number4
DOIs
StatePublished - Apr 2017

Keywords

  • Agrin
  • LRP4
  • MuSK
  • YAP
  • liver cancer
  • neuromuscular junction

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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