Alteration of cytokine profile following hemorrhagic shock

Sumin Lu, Alex Aguilar, Kumar Subramani, Ninu Poulose, Ahmar Ayub, Raghavan Pillai Raju

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Hemorrhage is one of the leading causes of death in patients with trauma. We recently demonstrated that resveratrol can improve cardiac function and prolong life following severe hemorrhagic injury (HI) in a rat model. The present work is focused on determining changes in NF-κB dependent gene expression in the heart and the systemic cytokine milieu following HI and the effect of resveratrol treatment. The results indicate an increase in phosphorylated NF-κB in the heart with a concomitant increase in the expression of NF-κB dependent genes following HI. There was also a significant increase of systemic cytokine levels, both pro and anti-inflammatory, following HI and resolution when treated with resveratrol. This study demonstrates the potential role NF-κB has in the physiological response to HI and the effectiveness of resveratrol in reducing immune activation.

Original languageEnglish (US)
Pages (from-to)35-38
Number of pages4
JournalCytokine
Volume81
DOIs
StatePublished - May 1 2016

Fingerprint

Hemorrhagic Shock
Cytokines
Wounds and Injuries
Gene expression
Rats
Anti-Inflammatory Agents
Genes
Chemical activation
resveratrol
Cause of Death
Hemorrhage
Gene Expression

Keywords

  • Hemorrhage
  • Inflammation
  • NFκB
  • Shock
  • Trauma

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Hematology
  • Molecular Biology

Cite this

Alteration of cytokine profile following hemorrhagic shock. / Lu, Sumin; Aguilar, Alex; Subramani, Kumar; Poulose, Ninu; Ayub, Ahmar; Raju, Raghavan Pillai.

In: Cytokine, Vol. 81, 01.05.2016, p. 35-38.

Research output: Contribution to journalArticle

Lu, S, Aguilar, A, Subramani, K, Poulose, N, Ayub, A & Raju, RP 2016, 'Alteration of cytokine profile following hemorrhagic shock', Cytokine, vol. 81, pp. 35-38. https://doi.org/10.1016/j.cyto.2016.01.022
Lu, Sumin ; Aguilar, Alex ; Subramani, Kumar ; Poulose, Ninu ; Ayub, Ahmar ; Raju, Raghavan Pillai. / Alteration of cytokine profile following hemorrhagic shock. In: Cytokine. 2016 ; Vol. 81. pp. 35-38.
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