Alterations in IRF1/IRF2 expression in acute myelogenous leukemia

H. D. Preisler, S. Perambakam, B. Li, W. T. Hsu, P. Venugopal, S. Creech, S. Sivaraman, N. Tanaka

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

The interferon response genes 1 and 2 have been shown to be involved in the regulation of differentiation and proliferation of cells of the myeloid series, with the former functioning as an anti-oncogene and the latter as an oncogene. In the study described here, the levels of expression of these two genes and the ratio of their expression were compared in AML and normal marrow. The ratio of gene expression was significantly less in AML marrow cells as compared to normal marrow cells [med ratio = 1.33 vs. 2.97, P = 0.003]. While the expression ratio was unaffected by the presence or absence of either ras or fms mutations, p53 mutations were associated with higher IRF1:IRF2 expression ratios that wt p53 genes [med = 1.701 vs. 1.135, P = 0.014]. Given the functional characteristics and the competitive nature of these two genes, it is possible that leukemic transformation is associated with a fall in IRF1:IRF2 ratios. Finally, the administration of IL4 can result in the normalization of the IRF1:IRF2 ratio in the marrow cells of some patients with AML.

Original languageEnglish (US)
Pages (from-to)23-31
Number of pages9
JournalAmerican Journal of Hematology
Volume68
Issue number1
DOIs
StatePublished - Aug 23 2001
Externally publishedYes

Keywords

  • Acute leukemia
  • IRF1
  • IRF2

ASJC Scopus subject areas

  • Hematology

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    Preisler, H. D., Perambakam, S., Li, B., Hsu, W. T., Venugopal, P., Creech, S., Sivaraman, S., & Tanaka, N. (2001). Alterations in IRF1/IRF2 expression in acute myelogenous leukemia. American Journal of Hematology, 68(1), 23-31. https://doi.org/10.1002/ajh.1144