Alterations in splenic architecture and the localization of anti-double-stranded DNA B cells in aged mice

Ashlyn S. Eaton-Bassiri, Laura Mandik-Nayak, Su Jean Seo, Michael P. Madaio, Michael P. Cancro, Jan Erikson

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Aging is characterized by a decline in humoral immunity and a concommitant increased incidence of anti-DNA and other autoantibodies. To define how the regulation of autoreactive B cells is altered with age, we have used BALB/c mice with an Ig heavy H chain transgene to track the fate of anti-double-stranded (ds) DNA B cells in vivo. In young adult mice, anti-dsDNA B cells are developmentally arrested and excluded from the splenic B cell follicle, whereas in most aged mice they are mature and localize within the B cell follicle. Furthermore, we have detailed global changes in lymphoid architecture that accompany aging: CD4+ T cells are found not only in the periarteriolar lymphoid sheath, but also in the B cell follicles, Strikingly, these disruptions are similar to those that precede serum anti-dsDNA antibody expression in autoimmune MRL-lpr/lpr mice.

Original languageEnglish (US)
Pages (from-to)915-926
Number of pages12
JournalInternational Immunology
Volume12
Issue number6
DOIs
StatePublished - 2000

Keywords

  • Anti-nuclear antibodies
  • Autoimmunity
  • Nephritis
  • Tolerance

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Eaton-Bassiri, A. S., Mandik-Nayak, L., Seo, S. J., Madaio, M. P., Cancro, M. P., & Erikson, J. (2000). Alterations in splenic architecture and the localization of anti-double-stranded DNA B cells in aged mice. International Immunology, 12(6), 915-926. https://doi.org/10.1093/intimm/12.6.915