Alterations in splenic architecture and the localization of anti-double-stranded DNA B cells in aged mice

Ashlyn S. Eaton-Bassiri, Laura Mandik-Nayak, Su Jean Seo, Michael P. Madaio, Michael P. Cancro, Jan Erikson

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Aging is characterized by a decline in humoral immunity and a concommitant increased incidence of anti-DNA and other autoantibodies. To define how the regulation of autoreactive B cells is altered with age, we have used BALB/c mice with an Ig heavy H chain transgene to track the fate of anti-double-stranded (ds) DNA B cells in vivo. In young adult mice, anti-dsDNA B cells are developmentally arrested and excluded from the splenic B cell follicle, whereas in most aged mice they are mature and localize within the B cell follicle. Furthermore, we have detailed global changes in lymphoid architecture that accompany aging: CD4+ T cells are found not only in the periarteriolar lymphoid sheath, but also in the B cell follicles, Strikingly, these disruptions are similar to those that precede serum anti-dsDNA antibody expression in autoimmune MRL-lpr/lpr mice.

Original languageEnglish (US)
Pages (from-to)915-926
Number of pages12
JournalInternational Immunology
Volume12
Issue number6
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

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B-Lymphocytes
DNA
Immunoglobulin Heavy Chains
Humoral Immunity
Transgenes
Autoantibodies
Young Adult
Anti-Idiotypic Antibodies
T-Lymphocytes
Incidence
Serum

Keywords

  • Anti-nuclear antibodies
  • Autoimmunity
  • Nephritis
  • Tolerance

ASJC Scopus subject areas

  • Immunology

Cite this

Eaton-Bassiri, A. S., Mandik-Nayak, L., Seo, S. J., Madaio, M. P., Cancro, M. P., & Erikson, J. (2000). Alterations in splenic architecture and the localization of anti-double-stranded DNA B cells in aged mice. International Immunology, 12(6), 915-926. https://doi.org/10.1093/intimm/12.6.915

Alterations in splenic architecture and the localization of anti-double-stranded DNA B cells in aged mice. / Eaton-Bassiri, Ashlyn S.; Mandik-Nayak, Laura; Seo, Su Jean; Madaio, Michael P.; Cancro, Michael P.; Erikson, Jan.

In: International Immunology, Vol. 12, No. 6, 01.01.2000, p. 915-926.

Research output: Contribution to journalArticle

Eaton-Bassiri, AS, Mandik-Nayak, L, Seo, SJ, Madaio, MP, Cancro, MP & Erikson, J 2000, 'Alterations in splenic architecture and the localization of anti-double-stranded DNA B cells in aged mice', International Immunology, vol. 12, no. 6, pp. 915-926. https://doi.org/10.1093/intimm/12.6.915
Eaton-Bassiri, Ashlyn S. ; Mandik-Nayak, Laura ; Seo, Su Jean ; Madaio, Michael P. ; Cancro, Michael P. ; Erikson, Jan. / Alterations in splenic architecture and the localization of anti-double-stranded DNA B cells in aged mice. In: International Immunology. 2000 ; Vol. 12, No. 6. pp. 915-926.
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