Alterations of Testicular Function in the Unilaterally Cryptorchid Rat

Brooks Allen Keel, Tom O. Abney

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Mature male Sprague-Dawley rats were either rendered unilaterally cryptorchid or used as intact controls. At 7, 14, 21, and 28 days postsurgery, five animals from each group were sacrificed, blood samples were collected, and the cryptorchid, eutopic, and intact control testes were removed. The cryptorchid testes weights decreased markedly below the controls while the weights of the eutopic testes did not vary from those of the controls. The levels of serum LH, FSH, and testosterone (T) did not significantly differ between the two groups throughout the study. The testicular content of T, expressed as nanograms per testis, decreased in the cryptorchid testes below control values from 30.6 ± 3.3 ng at 7 days to 10.8 ± 0.3 ng at 28 days while the content of the eutopic testes increased above controls from 71.1 ± 6.0 ng at 7 days to 131.7 ± 9.8 ng at 28 days. The cytoplasmic estrogen receptor level (3H-E2 bound/mg protein) of the cryptorchid testis increased threefold above control levels at 7 days and continued to rise to a sixfold increase above control levels at 28 days; the eutopic and control E2R levels did not vary throughout the study. While these data demonstrate that the steroidogenic capacity of the cryptorchid testis was reduced, the increased E2 binding capacity indicates that the viability of the Leydig cell population was not detrimentally altered during the experimental period. These data further suggest that as a result of unilateral cryptorchidism, a compensatory change occurred in the eutopic testis resulting in an increased steroidogenic capacity in vivo.

Original languageEnglish (US)
Pages (from-to)489-495
Number of pages7
JournalProceedings of the Society for Experimental Biology and Medicine
Volume166
Issue number4
DOIs
StatePublished - Jan 1 1981

Fingerprint

Testis
Rats
Level control
Estrogen Receptors
Testosterone
Weights and Measures
Animals
Cryptorchidism
Blood
Leydig Cells
Cells
Cytoplasmic and Nuclear Receptors
Sprague Dawley Rats
Proteins
Serum
Population

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Alterations of Testicular Function in the Unilaterally Cryptorchid Rat. / Keel, Brooks Allen; Abney, Tom O.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 166, No. 4, 01.01.1981, p. 489-495.

Research output: Contribution to journalArticle

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