Altered lipid metabolism in parvovirus-infected cells.

G. S. Schuster, Gretchen B Caughman, N. L. O'Dell

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A broad spectrum of cell lipid alterations are known to occur as a consequence of various viral infections. These changes include inhibition of lipid synthesis, stimulation of lipid synthesis and changes in the proportions of various lipids. The current study examined the effects of two parvoviruses on lipids of rat kidney (NRK) cells. Cells were infected with H-1 or Kilham rat virus (KRV) and the effects on 14C-acetate incorporation determined. Results showed that H-1 virus rapidly inhibited lipid formation (in 1 h) while KRV produced a similar effect beginning around 8 h. Pretreatment of the cells with cycloheximide did not alter this response. Fatty acid analysis by gas chromatography did not reveal major alterations in this component of total cell lipids although some fatty acids became undetectable by 18 h post-infection. The data suggest that these parvoviruses, especially H-1 virus, are able to rapidly alter lipid formation following infection and that this effect may be mediated by a virion component.

Original languageEnglish (US)
Pages (from-to)143-155
Number of pages13
JournalMicrobios
Volume66
Issue number268-269
StatePublished - Jan 1 1991

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Parvovirus
Lipid Metabolism
Lipids
H-1 parvovirus
Fatty Acids
Viruses
Virus Diseases
Cellular Structures
Cycloheximide
Infection
Virion
Gas Chromatography
Acetates
Kidney

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

Schuster, G. S., Caughman, G. B., & O'Dell, N. L. (1991). Altered lipid metabolism in parvovirus-infected cells. Microbios, 66(268-269), 143-155.

Altered lipid metabolism in parvovirus-infected cells. / Schuster, G. S.; Caughman, Gretchen B; O'Dell, N. L.

In: Microbios, Vol. 66, No. 268-269, 01.01.1991, p. 143-155.

Research output: Contribution to journalArticle

Schuster, GS, Caughman, GB & O'Dell, NL 1991, 'Altered lipid metabolism in parvovirus-infected cells.', Microbios, vol. 66, no. 268-269, pp. 143-155.
Schuster GS, Caughman GB, O'Dell NL. Altered lipid metabolism in parvovirus-infected cells. Microbios. 1991 Jan 1;66(268-269):143-155.
Schuster, G. S. ; Caughman, Gretchen B ; O'Dell, N. L. / Altered lipid metabolism in parvovirus-infected cells. In: Microbios. 1991 ; Vol. 66, No. 268-269. pp. 143-155.
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