Altered tryptophan metabolism as a paradigm for good and bad aspects of immune privilege in chronic inflammatory diseases

Lingqian Li, Lei Huang, Henrique P. Lemos, Mario Mautino, Andrew L. Mellor

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

The term "immune privilege" was coined to describe weak immunogenicity (hypo-immunity) that manifests in some transplant settings. We extended this concept to encompass hypo-immunity that manifests at local sites of inflammation relevant to clinical diseases. Here, we focus on emerging evidence that enhanced tryptophan catabolism is a key metabolic process that promotes and sustains induced immune privilege, and discuss the implications for exploiting this knowledge to improve treatments for hypo-immune and hyper-immune syndromes using strategies to manipulate tryptophan metabolism.

Original languageEnglish (US)
Article numberArticle 109
JournalFrontiers in immunology
Volume3
Issue numberMAY
DOIs
StatePublished - 2012

Keywords

  • IDO
  • Immunity
  • Inflammation
  • Regulation
  • Tolerance

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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