Alveolar ridge and maxillary sinus augmentation using rhBMP-2: A systematic review

Rubens Moreno de Freitas, Rubens Spin-Neto, Elcio Marcantonio Junior, Luís Antônio Violin Dias Pereira, Ulf Me Wikesjö, Cristiano Susin

Research output: Contribution to journalArticle

42 Scopus citations


Purpose: The aim of this systematic review was to evaluate clinical and safety data for recombinant human bone morphogenetic protein-2 (rhBMP-2) in an absorbable collagen sponge (ACS) carrier when used for alveolar ridge/maxillary sinus augmentation in humans. Materials and Methods: Clinical studies/case series published 1980 through June 2012 using rhBMP-2/ACS were searched. Studies meeting the following criteria were considered eligible for inclusion: >10 subjects at baseline and maxillary sinus or alveolar ridge augmentation not concomitant with implant placement. Results: Seven of 69 publications were eligible for review. rhBMP-2/ACS yielded clinically meaningful bone formation for maxillary sinus augmentation that would allow placement of regular dental implants without consistent differences between rhBMP-2 concentrations. Nevertheless, the statistical analysis showed that sinus augmentation following autogenous bone graft was significantly greater (mean bone height: 1.6mm, 95% CI: 0.5-2.7mm) than for rhBMP-2/ACS (rhBMP-2 at 1.5mg/mL). In extraction sockets, rhBMP-2/ACS maintained alveolar ridge height while enhancing alveolar ridge width. Safety reports did not represent concerns for the proposed indications. Conclusions: rhBMP-2/ACS appears a promising alternative to autogenous bone grafts for alveolar ridge/maxillary sinus augmentation; dose and carrier optimization may expand its efficacy, use, and clinical application.

Original languageEnglish (US)
Pages (from-to)e192-e201
JournalClinical implant dentistry and related research
Issue numberS1
StatePublished - Jan 1 2015


  • Alveolar ridge augmentation
  • BMP
  • Bone morphogenetic proteins
  • Bone regeneration
  • Maxillary sinus augmentation

ASJC Scopus subject areas

  • Oral Surgery
  • Dentistry(all)

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    de Freitas, R. M., Spin-Neto, R., Junior, E. M., Pereira, L. A. V. D., Wikesjö, U. M., & Susin, C. (2015). Alveolar ridge and maxillary sinus augmentation using rhBMP-2: A systematic review. Clinical implant dentistry and related research, 17(S1), e192-e201.