Alveolar ridge and maxillary sinus augmentation using rhBMP-2: A systematic review

Rubens Moreno de Freitas, Rubens Spin-Neto, Elcio Marcantonio Junior, Luís Antônio Violin Dias Pereira, Ulf Me Wikesjö, Cristiano Susin

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Purpose: The aim of this systematic review was to evaluate clinical and safety data for recombinant human bone morphogenetic protein-2 (rhBMP-2) in an absorbable collagen sponge (ACS) carrier when used for alveolar ridge/maxillary sinus augmentation in humans. Materials and Methods: Clinical studies/case series published 1980 through June 2012 using rhBMP-2/ACS were searched. Studies meeting the following criteria were considered eligible for inclusion: >10 subjects at baseline and maxillary sinus or alveolar ridge augmentation not concomitant with implant placement. Results: Seven of 69 publications were eligible for review. rhBMP-2/ACS yielded clinically meaningful bone formation for maxillary sinus augmentation that would allow placement of regular dental implants without consistent differences between rhBMP-2 concentrations. Nevertheless, the statistical analysis showed that sinus augmentation following autogenous bone graft was significantly greater (mean bone height: 1.6mm, 95% CI: 0.5-2.7mm) than for rhBMP-2/ACS (rhBMP-2 at 1.5mg/mL). In extraction sockets, rhBMP-2/ACS maintained alveolar ridge height while enhancing alveolar ridge width. Safety reports did not represent concerns for the proposed indications. Conclusions: rhBMP-2/ACS appears a promising alternative to autogenous bone grafts for alveolar ridge/maxillary sinus augmentation; dose and carrier optimization may expand its efficacy, use, and clinical application.

Original languageEnglish (US)
Pages (from-to)e192-e201
JournalClinical implant dentistry and related research
Volume17
Issue numberS1
DOIs
StatePublished - Jan 1 2015

Fingerprint

Alveolar Process
Maxillary Sinus
Porifera
Collagen
Alveolar Ridge Augmentation
Bone and Bones
Transplants
Safety
Dental Implants
recombinant human bone morphogenetic protein-2
Osteogenesis
Publications

Keywords

  • Alveolar ridge augmentation
  • BMP
  • Bone morphogenetic proteins
  • Bone regeneration
  • Maxillary sinus augmentation

ASJC Scopus subject areas

  • Oral Surgery
  • Dentistry(all)

Cite this

de Freitas, R. M., Spin-Neto, R., Junior, E. M., Pereira, L. A. V. D., Wikesjö, U. M., & Susin, C. (2015). Alveolar ridge and maxillary sinus augmentation using rhBMP-2: A systematic review. Clinical implant dentistry and related research, 17(S1), e192-e201. https://doi.org/10.1111/cid.12156

Alveolar ridge and maxillary sinus augmentation using rhBMP-2 : A systematic review. / de Freitas, Rubens Moreno; Spin-Neto, Rubens; Junior, Elcio Marcantonio; Pereira, Luís Antônio Violin Dias; Wikesjö, Ulf Me; Susin, Cristiano.

In: Clinical implant dentistry and related research, Vol. 17, No. S1, 01.01.2015, p. e192-e201.

Research output: Contribution to journalArticle

de Freitas, RM, Spin-Neto, R, Junior, EM, Pereira, LAVD, Wikesjö, UM & Susin, C 2015, 'Alveolar ridge and maxillary sinus augmentation using rhBMP-2: A systematic review', Clinical implant dentistry and related research, vol. 17, no. S1, pp. e192-e201. https://doi.org/10.1111/cid.12156
de Freitas RM, Spin-Neto R, Junior EM, Pereira LAVD, Wikesjö UM, Susin C. Alveolar ridge and maxillary sinus augmentation using rhBMP-2: A systematic review. Clinical implant dentistry and related research. 2015 Jan 1;17(S1):e192-e201. https://doi.org/10.1111/cid.12156
de Freitas, Rubens Moreno ; Spin-Neto, Rubens ; Junior, Elcio Marcantonio ; Pereira, Luís Antônio Violin Dias ; Wikesjö, Ulf Me ; Susin, Cristiano. / Alveolar ridge and maxillary sinus augmentation using rhBMP-2 : A systematic review. In: Clinical implant dentistry and related research. 2015 ; Vol. 17, No. S1. pp. e192-e201.
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