American College of Critical Care Medicine clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock

Alan L. Davis, Joseph A. Carcillo, Rajesh K. Aneja, Andreas J. Deymann, John C. Lin, Trung C. Nguyen, Regina S. Okhuysen-Cawley, Monica S. Relvas, Ranna A. Rozenfeld, Peter W. Skippen, Bonnie J. Stojadinovic, Eric A. Williams, Tim S. Yeh, Fran Balamuth, Joe Brierley, Allan R. De Caen, Ira M. Cheifetz, Karen Choong, Edward Conway, Timothy CornellAllan Doctor, Marc Andre Dugas, Jonathan D. Feldman, Julie C. Fitzgerald, Heidi R. Flori, James D. Fortenberry, Ana Lia Graciano, Bruce M. Greenwald, Mark W. Hall, Yong Yun Han, Lynn J. Hernan, Jose E. Irazuzta, Elizabeth Iselin, Elise W. Van Der Jagt, Howard E. Jeffries, Saraswati Kache, Chhavi Katyal, Niranjan Kissoon, Alexander A. Kon, Martha C. Kutko, Graeme MacLaren, Timothy Maul, Renuka Mehta, Fola Odetola, Kristine Parbuoni, Raina Paul, Mark J. Peters, Suchitra Ranjit, Karin E. Reuter-Rice, Eduardo J. Schnitzler, Halden F. Scott, Adalberto Torres, Jacki Weingarten-Abrams, Scott L. Weiss, Jerry J. Zimmerman, Aaron L. Zuckerberg

Research output: Contribution to journalReview article

99 Citations (Scopus)

Abstract

Objectives: The American College of Critical Care Medicine provided 2002 and 2007 guidelines for hemodynamic support of newborn and pediatric septic shock. Provide the 2014 update of the 2007 American College of Critical Care Medicine "Clinical Guidelines for Hemodynamic Support of Neonates and Children with Septic Shock." Design: Society of Critical Care Medicine members were identified from general solicitation at Society of Critical Care Medicine Educational and Scientific Symposia (2006-2014). The PubMed/Medline/Embase literature (2006-14) was searched by the Society of Critical Care Medicine librarian using the keywords: sepsis, septicemia, septic shock, endotoxemia, persistent pulmonary hypertension, nitric oxide, extracorporeal membrane oxygenation, and American College of Critical Care Medicine guidelines in the newborn and pediatric age groups. Measurements and Main Results: The 2002 and 2007 guidelines were widely disseminated, translated into Spanish and Portuguese, and incorporated into Society of Critical Care Medicine and American Heart Association/Pediatric Advanced Life Support sanctioned recommendations. The review of new literature highlights two tertiary pediatric centers that implemented quality improvement initiatives to improve early septic shock recognition and first-hour compliance to these guidelines. Improved compliance reduced hospital mortality from 4% to 2%. Analysis of Global Sepsis Initiative data in resource rich developed and developing nations further showed improved hospital mortality with compliance to first-hour and stabilization guideline recommendations. Conclusions: The major new recommendation in the 2014 update is consideration of institution-specific use of 1) a "recognition bundle" containing a trigger tool for rapid identification of patients with septic shock, 2) a "resuscitation and stabilization bundle" to help adherence to best practice principles, and 3) a "performance bundle" to identify and overcome perceived barriers to the pursuit of best practice principles.

Original languageEnglish (US)
Pages (from-to)1061-1093
Number of pages33
JournalCritical care medicine
Volume45
Issue number6
DOIs
StatePublished - Jan 1 2017

Fingerprint

Clinical Medicine
Critical Care
Septic Shock
Hemodynamics
Guidelines
Pediatrics
Sepsis
Newborn Infant
Hospital Mortality
Practice Guidelines
Medicine
Librarians
Extracorporeal Membrane Oxygenation
Endotoxemia
Quality Improvement
Developed Countries
Pulmonary Hypertension
PubMed
Resuscitation
Developing Countries

Keywords

  • Hemodynamics
  • Newborn
  • Pediatric
  • Septic shock

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Davis, A. L., Carcillo, J. A., Aneja, R. K., Deymann, A. J., Lin, J. C., Nguyen, T. C., ... Zuckerberg, A. L. (2017). American College of Critical Care Medicine clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock. Critical care medicine, 45(6), 1061-1093. https://doi.org/10.1097/CCM.0000000000002425

American College of Critical Care Medicine clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock. / Davis, Alan L.; Carcillo, Joseph A.; Aneja, Rajesh K.; Deymann, Andreas J.; Lin, John C.; Nguyen, Trung C.; Okhuysen-Cawley, Regina S.; Relvas, Monica S.; Rozenfeld, Ranna A.; Skippen, Peter W.; Stojadinovic, Bonnie J.; Williams, Eric A.; Yeh, Tim S.; Balamuth, Fran; Brierley, Joe; De Caen, Allan R.; Cheifetz, Ira M.; Choong, Karen; Conway, Edward; Cornell, Timothy; Doctor, Allan; Dugas, Marc Andre; Feldman, Jonathan D.; Fitzgerald, Julie C.; Flori, Heidi R.; Fortenberry, James D.; Graciano, Ana Lia; Greenwald, Bruce M.; Hall, Mark W.; Han, Yong Yun; Hernan, Lynn J.; Irazuzta, Jose E.; Iselin, Elizabeth; Van Der Jagt, Elise W.; Jeffries, Howard E.; Kache, Saraswati; Katyal, Chhavi; Kissoon, Niranjan; Kon, Alexander A.; Kutko, Martha C.; MacLaren, Graeme; Maul, Timothy; Mehta, Renuka; Odetola, Fola; Parbuoni, Kristine; Paul, Raina; Peters, Mark J.; Ranjit, Suchitra; Reuter-Rice, Karin E.; Schnitzler, Eduardo J.; Scott, Halden F.; Torres, Adalberto; Weingarten-Abrams, Jacki; Weiss, Scott L.; Zimmerman, Jerry J.; Zuckerberg, Aaron L.

In: Critical care medicine, Vol. 45, No. 6, 01.01.2017, p. 1061-1093.

Research output: Contribution to journalReview article

Davis, AL, Carcillo, JA, Aneja, RK, Deymann, AJ, Lin, JC, Nguyen, TC, Okhuysen-Cawley, RS, Relvas, MS, Rozenfeld, RA, Skippen, PW, Stojadinovic, BJ, Williams, EA, Yeh, TS, Balamuth, F, Brierley, J, De Caen, AR, Cheifetz, IM, Choong, K, Conway, E, Cornell, T, Doctor, A, Dugas, MA, Feldman, JD, Fitzgerald, JC, Flori, HR, Fortenberry, JD, Graciano, AL, Greenwald, BM, Hall, MW, Han, YY, Hernan, LJ, Irazuzta, JE, Iselin, E, Van Der Jagt, EW, Jeffries, HE, Kache, S, Katyal, C, Kissoon, N, Kon, AA, Kutko, MC, MacLaren, G, Maul, T, Mehta, R, Odetola, F, Parbuoni, K, Paul, R, Peters, MJ, Ranjit, S, Reuter-Rice, KE, Schnitzler, EJ, Scott, HF, Torres, A, Weingarten-Abrams, J, Weiss, SL, Zimmerman, JJ & Zuckerberg, AL 2017, 'American College of Critical Care Medicine clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock', Critical care medicine, vol. 45, no. 6, pp. 1061-1093. https://doi.org/10.1097/CCM.0000000000002425
Davis, Alan L. ; Carcillo, Joseph A. ; Aneja, Rajesh K. ; Deymann, Andreas J. ; Lin, John C. ; Nguyen, Trung C. ; Okhuysen-Cawley, Regina S. ; Relvas, Monica S. ; Rozenfeld, Ranna A. ; Skippen, Peter W. ; Stojadinovic, Bonnie J. ; Williams, Eric A. ; Yeh, Tim S. ; Balamuth, Fran ; Brierley, Joe ; De Caen, Allan R. ; Cheifetz, Ira M. ; Choong, Karen ; Conway, Edward ; Cornell, Timothy ; Doctor, Allan ; Dugas, Marc Andre ; Feldman, Jonathan D. ; Fitzgerald, Julie C. ; Flori, Heidi R. ; Fortenberry, James D. ; Graciano, Ana Lia ; Greenwald, Bruce M. ; Hall, Mark W. ; Han, Yong Yun ; Hernan, Lynn J. ; Irazuzta, Jose E. ; Iselin, Elizabeth ; Van Der Jagt, Elise W. ; Jeffries, Howard E. ; Kache, Saraswati ; Katyal, Chhavi ; Kissoon, Niranjan ; Kon, Alexander A. ; Kutko, Martha C. ; MacLaren, Graeme ; Maul, Timothy ; Mehta, Renuka ; Odetola, Fola ; Parbuoni, Kristine ; Paul, Raina ; Peters, Mark J. ; Ranjit, Suchitra ; Reuter-Rice, Karin E. ; Schnitzler, Eduardo J. ; Scott, Halden F. ; Torres, Adalberto ; Weingarten-Abrams, Jacki ; Weiss, Scott L. ; Zimmerman, Jerry J. ; Zuckerberg, Aaron L. / American College of Critical Care Medicine clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock. In: Critical care medicine. 2017 ; Vol. 45, No. 6. pp. 1061-1093.
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title = "American College of Critical Care Medicine clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock",
abstract = "Objectives: The American College of Critical Care Medicine provided 2002 and 2007 guidelines for hemodynamic support of newborn and pediatric septic shock. Provide the 2014 update of the 2007 American College of Critical Care Medicine {"}Clinical Guidelines for Hemodynamic Support of Neonates and Children with Septic Shock.{"} Design: Society of Critical Care Medicine members were identified from general solicitation at Society of Critical Care Medicine Educational and Scientific Symposia (2006-2014). The PubMed/Medline/Embase literature (2006-14) was searched by the Society of Critical Care Medicine librarian using the keywords: sepsis, septicemia, septic shock, endotoxemia, persistent pulmonary hypertension, nitric oxide, extracorporeal membrane oxygenation, and American College of Critical Care Medicine guidelines in the newborn and pediatric age groups. Measurements and Main Results: The 2002 and 2007 guidelines were widely disseminated, translated into Spanish and Portuguese, and incorporated into Society of Critical Care Medicine and American Heart Association/Pediatric Advanced Life Support sanctioned recommendations. The review of new literature highlights two tertiary pediatric centers that implemented quality improvement initiatives to improve early septic shock recognition and first-hour compliance to these guidelines. Improved compliance reduced hospital mortality from 4{\%} to 2{\%}. Analysis of Global Sepsis Initiative data in resource rich developed and developing nations further showed improved hospital mortality with compliance to first-hour and stabilization guideline recommendations. Conclusions: The major new recommendation in the 2014 update is consideration of institution-specific use of 1) a {"}recognition bundle{"} containing a trigger tool for rapid identification of patients with septic shock, 2) a {"}resuscitation and stabilization bundle{"} to help adherence to best practice principles, and 3) a {"}performance bundle{"} to identify and overcome perceived barriers to the pursuit of best practice principles.",
keywords = "Hemodynamics, Newborn, Pediatric, Septic shock",
author = "Davis, {Alan L.} and Carcillo, {Joseph A.} and Aneja, {Rajesh K.} and Deymann, {Andreas J.} and Lin, {John C.} and Nguyen, {Trung C.} and Okhuysen-Cawley, {Regina S.} and Relvas, {Monica S.} and Rozenfeld, {Ranna A.} and Skippen, {Peter W.} and Stojadinovic, {Bonnie J.} and Williams, {Eric A.} and Yeh, {Tim S.} and Fran Balamuth and Joe Brierley and {De Caen}, {Allan R.} and Cheifetz, {Ira M.} and Karen Choong and Edward Conway and Timothy Cornell and Allan Doctor and Dugas, {Marc Andre} and Feldman, {Jonathan D.} and Fitzgerald, {Julie C.} and Flori, {Heidi R.} and Fortenberry, {James D.} and Graciano, {Ana Lia} and Greenwald, {Bruce M.} and Hall, {Mark W.} and Han, {Yong Yun} and Hernan, {Lynn J.} and Irazuzta, {Jose E.} and Elizabeth Iselin and {Van Der Jagt}, {Elise W.} and Jeffries, {Howard E.} and Saraswati Kache and Chhavi Katyal and Niranjan Kissoon and Kon, {Alexander A.} and Kutko, {Martha C.} and Graeme MacLaren and Timothy Maul and Renuka Mehta and Fola Odetola and Kristine Parbuoni and Raina Paul and Peters, {Mark J.} and Suchitra Ranjit and Reuter-Rice, {Karin E.} and Schnitzler, {Eduardo J.} and Scott, {Halden F.} and Adalberto Torres and Jacki Weingarten-Abrams and Weiss, {Scott L.} and Zimmerman, {Jerry J.} and Zuckerberg, {Aaron L.}",
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T1 - American College of Critical Care Medicine clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock

AU - Davis, Alan L.

AU - Carcillo, Joseph A.

AU - Aneja, Rajesh K.

AU - Deymann, Andreas J.

AU - Lin, John C.

AU - Nguyen, Trung C.

AU - Okhuysen-Cawley, Regina S.

AU - Relvas, Monica S.

AU - Rozenfeld, Ranna A.

AU - Skippen, Peter W.

AU - Stojadinovic, Bonnie J.

AU - Williams, Eric A.

AU - Yeh, Tim S.

AU - Balamuth, Fran

AU - Brierley, Joe

AU - De Caen, Allan R.

AU - Cheifetz, Ira M.

AU - Choong, Karen

AU - Conway, Edward

AU - Cornell, Timothy

AU - Doctor, Allan

AU - Dugas, Marc Andre

AU - Feldman, Jonathan D.

AU - Fitzgerald, Julie C.

AU - Flori, Heidi R.

AU - Fortenberry, James D.

AU - Graciano, Ana Lia

AU - Greenwald, Bruce M.

AU - Hall, Mark W.

AU - Han, Yong Yun

AU - Hernan, Lynn J.

AU - Irazuzta, Jose E.

AU - Iselin, Elizabeth

AU - Van Der Jagt, Elise W.

AU - Jeffries, Howard E.

AU - Kache, Saraswati

AU - Katyal, Chhavi

AU - Kissoon, Niranjan

AU - Kon, Alexander A.

AU - Kutko, Martha C.

AU - MacLaren, Graeme

AU - Maul, Timothy

AU - Mehta, Renuka

AU - Odetola, Fola

AU - Parbuoni, Kristine

AU - Paul, Raina

AU - Peters, Mark J.

AU - Ranjit, Suchitra

AU - Reuter-Rice, Karin E.

AU - Schnitzler, Eduardo J.

AU - Scott, Halden F.

AU - Torres, Adalberto

AU - Weingarten-Abrams, Jacki

AU - Weiss, Scott L.

AU - Zimmerman, Jerry J.

AU - Zuckerberg, Aaron L.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Objectives: The American College of Critical Care Medicine provided 2002 and 2007 guidelines for hemodynamic support of newborn and pediatric septic shock. Provide the 2014 update of the 2007 American College of Critical Care Medicine "Clinical Guidelines for Hemodynamic Support of Neonates and Children with Septic Shock." Design: Society of Critical Care Medicine members were identified from general solicitation at Society of Critical Care Medicine Educational and Scientific Symposia (2006-2014). The PubMed/Medline/Embase literature (2006-14) was searched by the Society of Critical Care Medicine librarian using the keywords: sepsis, septicemia, septic shock, endotoxemia, persistent pulmonary hypertension, nitric oxide, extracorporeal membrane oxygenation, and American College of Critical Care Medicine guidelines in the newborn and pediatric age groups. Measurements and Main Results: The 2002 and 2007 guidelines were widely disseminated, translated into Spanish and Portuguese, and incorporated into Society of Critical Care Medicine and American Heart Association/Pediatric Advanced Life Support sanctioned recommendations. The review of new literature highlights two tertiary pediatric centers that implemented quality improvement initiatives to improve early septic shock recognition and first-hour compliance to these guidelines. Improved compliance reduced hospital mortality from 4% to 2%. Analysis of Global Sepsis Initiative data in resource rich developed and developing nations further showed improved hospital mortality with compliance to first-hour and stabilization guideline recommendations. Conclusions: The major new recommendation in the 2014 update is consideration of institution-specific use of 1) a "recognition bundle" containing a trigger tool for rapid identification of patients with septic shock, 2) a "resuscitation and stabilization bundle" to help adherence to best practice principles, and 3) a "performance bundle" to identify and overcome perceived barriers to the pursuit of best practice principles.

AB - Objectives: The American College of Critical Care Medicine provided 2002 and 2007 guidelines for hemodynamic support of newborn and pediatric septic shock. Provide the 2014 update of the 2007 American College of Critical Care Medicine "Clinical Guidelines for Hemodynamic Support of Neonates and Children with Septic Shock." Design: Society of Critical Care Medicine members were identified from general solicitation at Society of Critical Care Medicine Educational and Scientific Symposia (2006-2014). The PubMed/Medline/Embase literature (2006-14) was searched by the Society of Critical Care Medicine librarian using the keywords: sepsis, septicemia, septic shock, endotoxemia, persistent pulmonary hypertension, nitric oxide, extracorporeal membrane oxygenation, and American College of Critical Care Medicine guidelines in the newborn and pediatric age groups. Measurements and Main Results: The 2002 and 2007 guidelines were widely disseminated, translated into Spanish and Portuguese, and incorporated into Society of Critical Care Medicine and American Heart Association/Pediatric Advanced Life Support sanctioned recommendations. The review of new literature highlights two tertiary pediatric centers that implemented quality improvement initiatives to improve early septic shock recognition and first-hour compliance to these guidelines. Improved compliance reduced hospital mortality from 4% to 2%. Analysis of Global Sepsis Initiative data in resource rich developed and developing nations further showed improved hospital mortality with compliance to first-hour and stabilization guideline recommendations. Conclusions: The major new recommendation in the 2014 update is consideration of institution-specific use of 1) a "recognition bundle" containing a trigger tool for rapid identification of patients with septic shock, 2) a "resuscitation and stabilization bundle" to help adherence to best practice principles, and 3) a "performance bundle" to identify and overcome perceived barriers to the pursuit of best practice principles.

KW - Hemodynamics

KW - Newborn

KW - Pediatric

KW - Septic shock

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