Amnion

A potent graft source for cell therapy in stroke

Jin Yu Seong, Maddalena Soncini, Yuji Kaneko, David C Hess, Ornella Parolini, Cesar V. Borlongan

Research output: Contribution to journalReview article

65 Citations (Scopus)

Abstract

Regenerative medicine is a new field primarily based on the concept of transplanting exogenous or stimulating endogenous stem cells to generate biological substitutes and improve tissue functions. Recently, amnion-derived cells have been reported to have multipotent differentiation ability, and these cells have attracted attention as a novel cell source for cell transplantation therapy. Cells isolated from amniotic membrane can differentiate into all three germ layers, have low immunogenicity and anti-inflammatory function, and do not require the destruction of human embryos for their isolation, thus circumventing the ethical debate commonly associated with the use of human embryonic stem cells. Accumulating evidence now suggests that the amnion, which had been discarded after parturition, is a highly potent transplant material in the field of regenerative medicine. In this report, we review the current progress on the characterization of MSCs derived from the amnion as a remarkable transplantable cell population with therapeutic potential for multiple CNS disorders, especially stroke.

Original languageEnglish (US)
Pages (from-to)111-118
Number of pages8
JournalCell Transplantation
Volume18
Issue number2
DOIs
StatePublished - Jun 16 2009

Fingerprint

Amnion
Cell- and Tissue-Based Therapy
Stem cells
Grafts
Stroke
Transplants
Regenerative Medicine
Cells
Tissue
Membranes
Germ Layers
Cell Transplantation
Cell Differentiation
Anti-Inflammatory Agents
Stem Cells
Embryonic Structures
Parturition
Population
Therapeutics

Keywords

  • Adult stem cells
  • Cerebral ischemia
  • Mesenchymal stromal cells
  • Placenta
  • Progenitors
  • Transplantation

ASJC Scopus subject areas

  • Biomedical Engineering
  • Cell Biology
  • Transplantation

Cite this

Seong, J. Y., Soncini, M., Kaneko, Y., Hess, D. C., Parolini, O., & Borlongan, C. V. (2009). Amnion: A potent graft source for cell therapy in stroke. Cell Transplantation, 18(2), 111-118. https://doi.org/10.3727/096368909788341243

Amnion : A potent graft source for cell therapy in stroke. / Seong, Jin Yu; Soncini, Maddalena; Kaneko, Yuji; Hess, David C; Parolini, Ornella; Borlongan, Cesar V.

In: Cell Transplantation, Vol. 18, No. 2, 16.06.2009, p. 111-118.

Research output: Contribution to journalReview article

Seong, JY, Soncini, M, Kaneko, Y, Hess, DC, Parolini, O & Borlongan, CV 2009, 'Amnion: A potent graft source for cell therapy in stroke', Cell Transplantation, vol. 18, no. 2, pp. 111-118. https://doi.org/10.3727/096368909788341243
Seong JY, Soncini M, Kaneko Y, Hess DC, Parolini O, Borlongan CV. Amnion: A potent graft source for cell therapy in stroke. Cell Transplantation. 2009 Jun 16;18(2):111-118. https://doi.org/10.3727/096368909788341243
Seong, Jin Yu ; Soncini, Maddalena ; Kaneko, Yuji ; Hess, David C ; Parolini, Ornella ; Borlongan, Cesar V. / Amnion : A potent graft source for cell therapy in stroke. In: Cell Transplantation. 2009 ; Vol. 18, No. 2. pp. 111-118.
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