Amphiphilic gels with controlled mesh dimensions for insulin delivery

J. P. Kennedy, G. Fenyvesi, S. Na, B. Keszler, K. S. Rosenthal

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

A series of amphiphilic networks, poly(N,N-dimethylacrylamide)-1-polyisobutylene, with different hydrophilic to hydrophobic ratios were synthesized and thin-walled tubular membranes were prepared. The molecular weight cut-off ranges and the insulin and glucose diffusion coefficients and permeabilities were determined. Our results show a direct correlation between the Mc,hydrophilic and the permeability of the membrane. According to these studies, Mc,hydrophilic is the significant parameter that correlates with permeability, allowing selection of the appropriate membrane for development of a bioartificial pancreas.

Original languageEnglish (US)
Pages (from-to)710-711
Number of pages10
JournalACS Symposium Series
Volume833
Issue number1
StatePublished - Dec 1 2002
EventThe San Francisco Meeting - San Francisco, CA, USA
Duration: Mar 26 2000Mar 31 2000

ASJC Scopus subject areas

  • Polymers and Plastics

Fingerprint Dive into the research topics of 'Amphiphilic gels with controlled mesh dimensions for insulin delivery'. Together they form a unique fingerprint.

  • Cite this

    Kennedy, J. P., Fenyvesi, G., Na, S., Keszler, B., & Rosenthal, K. S. (2002). Amphiphilic gels with controlled mesh dimensions for insulin delivery. ACS Symposium Series, 833(1), 710-711.