AMPK/mTOR Signaling in Autophagy Regulation During Cisplatin-Induced Acute Kidney Injury

Ying Wang, Zhiwen Liu, Shaoqun Shu, Juan Cai, Chengyuan Tang, Zheng Dong

Research output: Contribution to journalReview articlepeer-review

Abstract

Autophagy is a conserved, multistep pathway that degrades and recycles dysfunctional organelles and macromolecules to maintain cellular homeostasis. Mammalian target of rapamycin (mTOR) and adenosine-monophosphate activated-protein kinase (AMPK) are major negative and positive regulators of autophagy, respectively. In cisplatin-induced acute kidney injury (AKI) or nephrotoxicity, autophagy is rapidly induced in renal tubular epithelial cells and acts as a cytoprotective mechanism for cell survival. Both mTOR and AMPK have been implicated in the regulation of autophagy in cisplatin-induced AKI. Targeting mTOR and/or AMPK may offer effective strategies for kidney protection during cisplatin-mediated chemotherapy.

Original languageEnglish (US)
Article number619730
JournalFrontiers in Physiology
Volume11
DOIs
StatePublished - Dec 17 2020

Keywords

  • AMPK
  • acute kidney injury
  • autophagy
  • cisplatin
  • mTOR
  • nephrotoxicity

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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