An 8-month exercise intervention alters frontotemporal white matter integrity in overweight children

David J. Schaeffer, Cynthia E. Krafft, Nicolette F. Schwarz, Lingxi Chi, Amanda L. Rodrigue, Jordan E. Pierce, Jerry David Allison, Nathan Eugene Yanasak, Tianming Liu, Catherine Lucy Davis, Jennifer E. McDowell

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

In childhood, excess adiposity and low fitness are linked to poor academic performance, lower cognitive function, and differences in brain structure. Identifying ways to mitigate obesity-related alterations is of current clinical importance. This study examined the effects of an 8-month exercise intervention on the uncinate fasciculus, a white matter fiber tract connecting frontal and temporal lobes. Participants consisted of 18 unfit, overweight 8- to 11-year-old children (94% Black) who were randomly assigned to either an aerobic exercise (n=10) or a sedentary control group (n=8). Before and after the intervention, all subjects participated in a diffusion tensor MRI scan. Tractography was conducted to isolate the uncinate fasciculus. The exercise group showed improved white matter integrity as compared to the control group. These findings are consistent with an emerging literature suggesting beneficial effects of exercise on white matter integrity.

Original languageEnglish (US)
Pages (from-to)728-733
Number of pages6
JournalPsychophysiology
Volume51
Issue number8
DOIs
StatePublished - Aug 2014

Fingerprint

Exercise
Control Groups
Diffusion Magnetic Resonance Imaging
Adiposity
Frontal Lobe
Temporal Lobe
Cognition
Obesity
Magnetic Resonance Imaging
White Matter
Brain

Keywords

  • Children
  • Diffusion tensor imaging
  • Exercise
  • Obesity
  • Uncinate fasciculus

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Neurology
  • Endocrine and Autonomic Systems
  • Developmental Neuroscience
  • Cognitive Neuroscience
  • Biological Psychiatry

Cite this

Schaeffer, D. J., Krafft, C. E., Schwarz, N. F., Chi, L., Rodrigue, A. L., Pierce, J. E., ... McDowell, J. E. (2014). An 8-month exercise intervention alters frontotemporal white matter integrity in overweight children. Psychophysiology, 51(8), 728-733. https://doi.org/10.1111/psyp.12227

An 8-month exercise intervention alters frontotemporal white matter integrity in overweight children. / Schaeffer, David J.; Krafft, Cynthia E.; Schwarz, Nicolette F.; Chi, Lingxi; Rodrigue, Amanda L.; Pierce, Jordan E.; Allison, Jerry David; Yanasak, Nathan Eugene; Liu, Tianming; Davis, Catherine Lucy; McDowell, Jennifer E.

In: Psychophysiology, Vol. 51, No. 8, 08.2014, p. 728-733.

Research output: Contribution to journalArticle

Schaeffer, DJ, Krafft, CE, Schwarz, NF, Chi, L, Rodrigue, AL, Pierce, JE, Allison, JD, Yanasak, NE, Liu, T, Davis, CL & McDowell, JE 2014, 'An 8-month exercise intervention alters frontotemporal white matter integrity in overweight children', Psychophysiology, vol. 51, no. 8, pp. 728-733. https://doi.org/10.1111/psyp.12227
Schaeffer DJ, Krafft CE, Schwarz NF, Chi L, Rodrigue AL, Pierce JE et al. An 8-month exercise intervention alters frontotemporal white matter integrity in overweight children. Psychophysiology. 2014 Aug;51(8):728-733. https://doi.org/10.1111/psyp.12227
Schaeffer, David J. ; Krafft, Cynthia E. ; Schwarz, Nicolette F. ; Chi, Lingxi ; Rodrigue, Amanda L. ; Pierce, Jordan E. ; Allison, Jerry David ; Yanasak, Nathan Eugene ; Liu, Tianming ; Davis, Catherine Lucy ; McDowell, Jennifer E. / An 8-month exercise intervention alters frontotemporal white matter integrity in overweight children. In: Psychophysiology. 2014 ; Vol. 51, No. 8. pp. 728-733.
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