An Efficient Greener Approach for N-acylation of Amines in Water Using Benzotriazole Chemistry

Tarek S. Ibrahim, Israa A. Seliem, Siva S. Panda, Amany M.M. Al-Mahmoudy, Zakaria K.M. Abdel-Samii, Nabil A. Alhakamy, Hani Z. Asfour, Mohamed Elagawany

Research output: Contribution to journalArticle

Abstract

A straightforward, mild and cost-efficient synthesis of various arylamides in water was accomplished using versatile benzotriazole chemistry. Acylation of various amines was achieved in water at room temperature as well as under microwave irradiation. The developed protocol unfolds the synthesis of amino acid aryl amides, drug conjugates and benzimidazoles. The environmentally friendly synthesis, short reaction time, simple workup, high yields, mild conditions and free of racemization are the key advantages of this protocol.

Original languageEnglish (US)
Article number2501
JournalMolecules
Volume25
Issue number11
DOIs
StatePublished - Jun 1 2020

Keywords

  • Acylation
  • Aryl amide
  • Benzimidazole
  • Benzotriazole chemistry
  • Green chemistry
  • Microwave
  • One-pot synthesis

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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  • Cite this

    Ibrahim, T. S., Seliem, I. A., Panda, S. S., Al-Mahmoudy, A. M. M., Abdel-Samii, Z. K. M., Alhakamy, N. A., Asfour, H. Z., & Elagawany, M. (2020). An Efficient Greener Approach for N-acylation of Amines in Water Using Benzotriazole Chemistry. Molecules, 25(11), [2501]. https://doi.org/10.3390/molecules25112501