Abstract
A straightforward, mild and cost-efficient synthesis of various arylamides in water was accomplished using versatile benzotriazole chemistry. Acylation of various amines was achieved in water at room temperature as well as under microwave irradiation. The developed protocol unfolds the synthesis of amino acid aryl amides, drug conjugates and benzimidazoles. The environmentally friendly synthesis, short reaction time, simple workup, high yields, mild conditions and free of racemization are the key advantages of this protocol.
Original language | English (US) |
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Article number | 2501 |
Journal | Molecules |
Volume | 25 |
Issue number | 11 |
DOIs | |
State | Published - Jun 1 2020 |
Keywords
- Acylation
- Aryl amide
- Benzimidazole
- Benzotriazole chemistry
- Green chemistry
- Microwave
- One-pot synthesis
ASJC Scopus subject areas
- Analytical Chemistry
- Chemistry (miscellaneous)
- Molecular Medicine
- Pharmaceutical Science
- Drug Discovery
- Physical and Theoretical Chemistry
- Organic Chemistry