An evaluation of a 2% erythromycin ointment in the topical therapy of acne vulgaris

Jack L Lesher, Dan K. Chalker, J. Graham Smith, Lyn C. Guenther, Charles N. Ellis, John J. Voorhees, Alan R. Shalita, Harry C. Klauda

Research output: Contribution to journalLetter

32 Citations (Scopus)

Abstract

Two hundred eight patients completed a 12-week, multicenter, double-blind, controlled study comparing a 2% erythromycin ointment to its vehicle. Patients were evaluated by inflammatory lesion counts and Cook acne severity grade at the initial visit and at weeks 2, 4, 8, 10, and 12. The 2% erythromycin ointment proved to be statistically more effective than the vehicle in reducing lesion counts and acne severity grade at weeks 4, 8, 10, and 12. The ointment caused few side effects and was well tolerated by most patients.

Original languageEnglish (US)
Pages (from-to)526-531
Number of pages6
JournalJournal of the American Academy of Dermatology
Volume12
Issue number3
DOIs
StatePublished - Jan 1 1985

Fingerprint

Acne Vulgaris
Erythromycin
Ointments
Double-Blind Method
Therapeutics

ASJC Scopus subject areas

  • Dermatology

Cite this

Lesher, J. L., Chalker, D. K., Smith, J. G., Guenther, L. C., Ellis, C. N., Voorhees, J. J., ... Klauda, H. C. (1985). An evaluation of a 2% erythromycin ointment in the topical therapy of acne vulgaris. Journal of the American Academy of Dermatology, 12(3), 526-531. https://doi.org/10.1016/S0190-9622(85)70074-6

An evaluation of a 2% erythromycin ointment in the topical therapy of acne vulgaris. / Lesher, Jack L; Chalker, Dan K.; Smith, J. Graham; Guenther, Lyn C.; Ellis, Charles N.; Voorhees, John J.; Shalita, Alan R.; Klauda, Harry C.

In: Journal of the American Academy of Dermatology, Vol. 12, No. 3, 01.01.1985, p. 526-531.

Research output: Contribution to journalLetter

Lesher, JL, Chalker, DK, Smith, JG, Guenther, LC, Ellis, CN, Voorhees, JJ, Shalita, AR & Klauda, HC 1985, 'An evaluation of a 2% erythromycin ointment in the topical therapy of acne vulgaris', Journal of the American Academy of Dermatology, vol. 12, no. 3, pp. 526-531. https://doi.org/10.1016/S0190-9622(85)70074-6
Lesher, Jack L ; Chalker, Dan K. ; Smith, J. Graham ; Guenther, Lyn C. ; Ellis, Charles N. ; Voorhees, John J. ; Shalita, Alan R. ; Klauda, Harry C. / An evaluation of a 2% erythromycin ointment in the topical therapy of acne vulgaris. In: Journal of the American Academy of Dermatology. 1985 ; Vol. 12, No. 3. pp. 526-531.
@article{ae9eb97b69e74073807f6be9bfb47396,
title = "An evaluation of a 2{\%} erythromycin ointment in the topical therapy of acne vulgaris",
abstract = "Two hundred eight patients completed a 12-week, multicenter, double-blind, controlled study comparing a 2{\%} erythromycin ointment to its vehicle. Patients were evaluated by inflammatory lesion counts and Cook acne severity grade at the initial visit and at weeks 2, 4, 8, 10, and 12. The 2{\%} erythromycin ointment proved to be statistically more effective than the vehicle in reducing lesion counts and acne severity grade at weeks 4, 8, 10, and 12. The ointment caused few side effects and was well tolerated by most patients.",
author = "Lesher, {Jack L} and Chalker, {Dan K.} and Smith, {J. Graham} and Guenther, {Lyn C.} and Ellis, {Charles N.} and Voorhees, {John J.} and Shalita, {Alan R.} and Klauda, {Harry C.}",
year = "1985",
month = "1",
day = "1",
doi = "10.1016/S0190-9622(85)70074-6",
language = "English (US)",
volume = "12",
pages = "526--531",
journal = "Journal of the American Academy of Dermatology",
issn = "0190-9622",
publisher = "Mosby Inc.",
number = "3",

}

TY - JOUR

T1 - An evaluation of a 2% erythromycin ointment in the topical therapy of acne vulgaris

AU - Lesher, Jack L

AU - Chalker, Dan K.

AU - Smith, J. Graham

AU - Guenther, Lyn C.

AU - Ellis, Charles N.

AU - Voorhees, John J.

AU - Shalita, Alan R.

AU - Klauda, Harry C.

PY - 1985/1/1

Y1 - 1985/1/1

N2 - Two hundred eight patients completed a 12-week, multicenter, double-blind, controlled study comparing a 2% erythromycin ointment to its vehicle. Patients were evaluated by inflammatory lesion counts and Cook acne severity grade at the initial visit and at weeks 2, 4, 8, 10, and 12. The 2% erythromycin ointment proved to be statistically more effective than the vehicle in reducing lesion counts and acne severity grade at weeks 4, 8, 10, and 12. The ointment caused few side effects and was well tolerated by most patients.

AB - Two hundred eight patients completed a 12-week, multicenter, double-blind, controlled study comparing a 2% erythromycin ointment to its vehicle. Patients were evaluated by inflammatory lesion counts and Cook acne severity grade at the initial visit and at weeks 2, 4, 8, 10, and 12. The 2% erythromycin ointment proved to be statistically more effective than the vehicle in reducing lesion counts and acne severity grade at weeks 4, 8, 10, and 12. The ointment caused few side effects and was well tolerated by most patients.

UR - http://www.scopus.com/inward/record.url?scp=0021920565&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021920565&partnerID=8YFLogxK

U2 - 10.1016/S0190-9622(85)70074-6

DO - 10.1016/S0190-9622(85)70074-6

M3 - Letter

C2 - 3157709

AN - SCOPUS:0021920565

VL - 12

SP - 526

EP - 531

JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

SN - 0190-9622

IS - 3

ER -