An update on genomic-guided therapies for pediatric solid tumors

Pui Chi Tsui, Yin Fai Lee, Zoey Wing Yee Liu, Laura Ren Huey Ip, Wenying Piao, Alan Kwok Shing Chiang, Vivian Wai Yan Lui

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Currently, out of the 82 US FDA-approved targeted therapies for adult cancer treatments, only three are approved for use in children irrespective of their genomic status. Apart from leukemia, only a handful of genomic-based trials involving children with solid tumors are ongoing. Emerging genomic data for pediatric solid tumors may facilitate the development of precision medicine in pediatric patients. Here, we provide an up-to-date review of all reported genomic aberrations in the eight most common pediatric solid tumors with whole-exome sequencing or whole-genome sequencing data (from cBioPortal database, Pediatric Cancer Genome Project, Therapeutically Applicable Research to Generate Effective Treatments) and additional non-whole-exome sequencing studies. Potential druggable events are highlighted and discussed so as to facilitate preclinical and clinical research in this area.

Original languageEnglish (US)
Pages (from-to)1345-1358
Number of pages14
JournalFuture Oncology
Volume13
Issue number15
DOIs
StatePublished - Jun 2017
Externally publishedYes

Keywords

  • clinical trials on targeted therapies
  • pediatric solid tumors
  • whole-exome sequencing

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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