Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma

Puya Gharahkhani, Kathryn P. Burdon, Jessica N. Cooke Bailey, Alex W. Hewitt, Matthew H. Law, Louis R. Pasquale, Jae H. Kang, Jonathan L. Haines, Emmanuelle Souzeau, Tiger Zhou, Owen M. Siggs, John Landers, Mona Awadalla, Shiwani Sharma, Richard A. Mills, Bronwyn Ridge, David Lynn, Robert Casson, Stuart L. Graham, Ivan Goldberg & 45 others Andrew White, Paul R. Healey, John Grigg, Mitchell Lawlor, Paul Mitchell, Jonathan Ruddle, Michael Coote, Mark Walland, Stephen Best, Andrea Vincent, Jesse Gale, Graham Radfordsmith, David C. Whiteman, Grant W. Montgomery, Nicholas G. Martin, David A. MacKey, Janey L. Wiggs, Stuart MacGregor, Jamie E. Craig, R. Rand Allingham, Murray Brilliant, Donald L. Budenz, John H. Fingert, Douglas Gaasterland, Teresa Gaasterland, Lisa Hark, Michael Hauser, Robert P. Igo, Peter Kraft, Richard K. Lee, Paul R. Lichter, Yutao Liu, Syoko Moroi, Margaret Pericak-Vance, Anthony Realini, Doug Rhee, Julia E. Richards, Robert Ritch, Joel S. Schuman, William K. Scott, Kuldev Singh, Arthur J. Sit, Douglas Vollrath, Gadi Wollstein, Donald J. Zack

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Open-angle glaucoma (OAG) is a major cause of blindness worldwide. To identify new risk loci for OAG, we performed a genome-wide association study in 3,071 OAG cases and 6,750 unscreened controls, and meta-analysed the results with GWAS data for intraocular pressure (IOP) and optic disc parameters (the overall meta-analysis sample size varying between 32,000 to 48,000 participants), which are glaucoma-related traits. We identified and independently validated four novel genome-wide significant associations within or near MYOF and CYP26A1, LINC02052 and CRYGS, LMX1B, and LMO7 using single variant tests, one additional locus (C9) using gene-based tests, and two genetic pathways-"response to fluid shear stress" and "abnormal retina morphology"-in pathway-based tests. Interestingly, some of the new risk loci contribute to risk of other genetically-correlated eye diseases including myopia and age-related macular degeneration. To our knowledge, this study is the first integrative study to combine genetic data from OAG and its correlated traits to identify new risk variants and genetic pathways, highlighting the future potential of combining genetic data from genetically-correlated eye traits for the purpose of gene discovery and mapping.

Original languageEnglish (US)
Article number3124
JournalScientific Reports
Volume8
Issue number1
DOIs
StatePublished - Dec 1 2018

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Open Angle Glaucoma
Glaucoma
Genome-Wide Association Study
Eye Diseases
Chromosome Mapping
Optic Disk
Myopia
Macular Degeneration
Genetic Association Studies
Blindness
Intraocular Pressure
Sample Size
Retina
Meta-Analysis
Genome
Genes

ASJC Scopus subject areas

  • General

Cite this

Gharahkhani, P., Burdon, K. P., Cooke Bailey, J. N., Hewitt, A. W., Law, M. H., Pasquale, L. R., ... Zack, D. J. (2018). Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma. Scientific Reports, 8(1), [3124]. https://doi.org/10.1038/s41598-018-20435-9

Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma. / Gharahkhani, Puya; Burdon, Kathryn P.; Cooke Bailey, Jessica N.; Hewitt, Alex W.; Law, Matthew H.; Pasquale, Louis R.; Kang, Jae H.; Haines, Jonathan L.; Souzeau, Emmanuelle; Zhou, Tiger; Siggs, Owen M.; Landers, John; Awadalla, Mona; Sharma, Shiwani; Mills, Richard A.; Ridge, Bronwyn; Lynn, David; Casson, Robert; Graham, Stuart L.; Goldberg, Ivan; White, Andrew; Healey, Paul R.; Grigg, John; Lawlor, Mitchell; Mitchell, Paul; Ruddle, Jonathan; Coote, Michael; Walland, Mark; Best, Stephen; Vincent, Andrea; Gale, Jesse; Radfordsmith, Graham; Whiteman, David C.; Montgomery, Grant W.; Martin, Nicholas G.; MacKey, David A.; Wiggs, Janey L.; MacGregor, Stuart; Craig, Jamie E.; Allingham, R. Rand; Brilliant, Murray; Budenz, Donald L.; Fingert, John H.; Gaasterland, Douglas; Gaasterland, Teresa; Hark, Lisa; Hauser, Michael; Igo, Robert P.; Kraft, Peter; Lee, Richard K.; Lichter, Paul R.; Liu, Yutao; Moroi, Syoko; Pericak-Vance, Margaret; Realini, Anthony; Rhee, Doug; Richards, Julia E.; Ritch, Robert; Schuman, Joel S.; Scott, William K.; Singh, Kuldev; Sit, Arthur J.; Vollrath, Douglas; Wollstein, Gadi; Zack, Donald J.

In: Scientific Reports, Vol. 8, No. 1, 3124, 01.12.2018.

Research output: Contribution to journalArticle

Gharahkhani, P, Burdon, KP, Cooke Bailey, JN, Hewitt, AW, Law, MH, Pasquale, LR, Kang, JH, Haines, JL, Souzeau, E, Zhou, T, Siggs, OM, Landers, J, Awadalla, M, Sharma, S, Mills, RA, Ridge, B, Lynn, D, Casson, R, Graham, SL, Goldberg, I, White, A, Healey, PR, Grigg, J, Lawlor, M, Mitchell, P, Ruddle, J, Coote, M, Walland, M, Best, S, Vincent, A, Gale, J, Radfordsmith, G, Whiteman, DC, Montgomery, GW, Martin, NG, MacKey, DA, Wiggs, JL, MacGregor, S, Craig, JE, Allingham, RR, Brilliant, M, Budenz, DL, Fingert, JH, Gaasterland, D, Gaasterland, T, Hark, L, Hauser, M, Igo, RP, Kraft, P, Lee, RK, Lichter, PR, Liu, Y, Moroi, S, Pericak-Vance, M, Realini, A, Rhee, D, Richards, JE, Ritch, R, Schuman, JS, Scott, WK, Singh, K, Sit, AJ, Vollrath, D, Wollstein, G & Zack, DJ 2018, 'Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma', Scientific Reports, vol. 8, no. 1, 3124. https://doi.org/10.1038/s41598-018-20435-9
Gharahkhani P, Burdon KP, Cooke Bailey JN, Hewitt AW, Law MH, Pasquale LR et al. Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma. Scientific Reports. 2018 Dec 1;8(1). 3124. https://doi.org/10.1038/s41598-018-20435-9
Gharahkhani, Puya ; Burdon, Kathryn P. ; Cooke Bailey, Jessica N. ; Hewitt, Alex W. ; Law, Matthew H. ; Pasquale, Louis R. ; Kang, Jae H. ; Haines, Jonathan L. ; Souzeau, Emmanuelle ; Zhou, Tiger ; Siggs, Owen M. ; Landers, John ; Awadalla, Mona ; Sharma, Shiwani ; Mills, Richard A. ; Ridge, Bronwyn ; Lynn, David ; Casson, Robert ; Graham, Stuart L. ; Goldberg, Ivan ; White, Andrew ; Healey, Paul R. ; Grigg, John ; Lawlor, Mitchell ; Mitchell, Paul ; Ruddle, Jonathan ; Coote, Michael ; Walland, Mark ; Best, Stephen ; Vincent, Andrea ; Gale, Jesse ; Radfordsmith, Graham ; Whiteman, David C. ; Montgomery, Grant W. ; Martin, Nicholas G. ; MacKey, David A. ; Wiggs, Janey L. ; MacGregor, Stuart ; Craig, Jamie E. ; Allingham, R. Rand ; Brilliant, Murray ; Budenz, Donald L. ; Fingert, John H. ; Gaasterland, Douglas ; Gaasterland, Teresa ; Hark, Lisa ; Hauser, Michael ; Igo, Robert P. ; Kraft, Peter ; Lee, Richard K. ; Lichter, Paul R. ; Liu, Yutao ; Moroi, Syoko ; Pericak-Vance, Margaret ; Realini, Anthony ; Rhee, Doug ; Richards, Julia E. ; Ritch, Robert ; Schuman, Joel S. ; Scott, William K. ; Singh, Kuldev ; Sit, Arthur J. ; Vollrath, Douglas ; Wollstein, Gadi ; Zack, Donald J. / Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma. In: Scientific Reports. 2018 ; Vol. 8, No. 1.
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abstract = "Open-angle glaucoma (OAG) is a major cause of blindness worldwide. To identify new risk loci for OAG, we performed a genome-wide association study in 3,071 OAG cases and 6,750 unscreened controls, and meta-analysed the results with GWAS data for intraocular pressure (IOP) and optic disc parameters (the overall meta-analysis sample size varying between 32,000 to 48,000 participants), which are glaucoma-related traits. We identified and independently validated four novel genome-wide significant associations within or near MYOF and CYP26A1, LINC02052 and CRYGS, LMX1B, and LMO7 using single variant tests, one additional locus (C9) using gene-based tests, and two genetic pathways-{"}response to fluid shear stress{"} and {"}abnormal retina morphology{"}-in pathway-based tests. Interestingly, some of the new risk loci contribute to risk of other genetically-correlated eye diseases including myopia and age-related macular degeneration. To our knowledge, this study is the first integrative study to combine genetic data from OAG and its correlated traits to identify new risk variants and genetic pathways, highlighting the future potential of combining genetic data from genetically-correlated eye traits for the purpose of gene discovery and mapping.",
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AU - Burdon, Kathryn P.

AU - Cooke Bailey, Jessica N.

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AU - Law, Matthew H.

AU - Pasquale, Louis R.

AU - Kang, Jae H.

AU - Haines, Jonathan L.

AU - Souzeau, Emmanuelle

AU - Zhou, Tiger

AU - Siggs, Owen M.

AU - Landers, John

AU - Awadalla, Mona

AU - Sharma, Shiwani

AU - Mills, Richard A.

AU - Ridge, Bronwyn

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AU - White, Andrew

AU - Healey, Paul R.

AU - Grigg, John

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AU - Lee, Richard K.

AU - Lichter, Paul R.

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