Analysis of cyclin dependent kinase inhibitors in malignant astrocytomas

Cargill H. Alleyne, Ju He, Jing Yang, Stephen B. Hunter, George Cotsonis, C. David James, Jeffrey J. Olson

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

The cyclin-dependent kinase inhibitors p16, p21, and p27 in human brain, and brain tumors were examined to explore clinicopathologic correlations. Western analysis and immunohistochemistry was performed and correlated retrospectively with the patients clinical characteristics. A trend was found between increased progression-free survival and p27 expression. There was no correlation between p27 expression and age or gender. The expression of p27 in malignant gliomas may have prognostic value. In addition, an investigation of the therapeutic benefit of overexpression of this cyclin-dependent kinase inhibitor is warranted given reports of diminished malignant potential of tumors expressing p27.

Original languageEnglish (US)
Pages (from-to)1111-1116
Number of pages6
JournalInternational journal of oncology
Volume14
Issue number6
DOIs
StatePublished - Jun 1999

Keywords

  • Brain neoplasm
  • Cyclin-dependent kinase inhibitor
  • Malignant astrocytoma
  • p16
  • p21
  • p27

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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