Analysis of cyclin dependent kinase inhibitors in malignant astrocytomas

Cargill Herley Alleyne, Ju He, Jing Yang, Stephen B. Hunter, George Cotsonis, C. David James, Jeffrey J. Olson

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The cyclin-dependent kinase inhibitors p16, p21, and p27 in human brain, and brain tumors were examined to explore clinicopathologic correlations. Western analysis and immunohistochemistry was performed and correlated retrospectively with the patients clinical characteristics. A trend was found between increased progression-free survival and p27 expression. There was no correlation between p27 expression and age or gender. The expression of p27 in malignant gliomas may have prognostic value. In addition, an investigation of the therapeutic benefit of overexpression of this cyclin-dependent kinase inhibitor is warranted given reports of diminished malignant potential of tumors expressing p27.

Original languageEnglish (US)
Pages (from-to)1111-1116
Number of pages6
JournalInternational Journal of Oncology
Volume14
Issue number6
StatePublished - Jun 1 1999

Fingerprint

Cyclin-Dependent Kinase Inhibitor p16
Cyclin-Dependent Kinase Inhibitor p21
Cyclin-Dependent Kinase Inhibitor p27
Cyclin-Dependent Kinases
Astrocytoma
Brain Neoplasms
Glioma
Disease-Free Survival
Immunohistochemistry
Brain
Neoplasms
Therapeutics

Keywords

  • Brain neoplasm
  • Cyclin-dependent kinase inhibitor
  • Malignant astrocytoma
  • p16
  • p21
  • p27

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Alleyne, C. H., He, J., Yang, J., Hunter, S. B., Cotsonis, G., James, C. D., & Olson, J. J. (1999). Analysis of cyclin dependent kinase inhibitors in malignant astrocytomas. International Journal of Oncology, 14(6), 1111-1116.

Analysis of cyclin dependent kinase inhibitors in malignant astrocytomas. / Alleyne, Cargill Herley; He, Ju; Yang, Jing; Hunter, Stephen B.; Cotsonis, George; James, C. David; Olson, Jeffrey J.

In: International Journal of Oncology, Vol. 14, No. 6, 01.06.1999, p. 1111-1116.

Research output: Contribution to journalArticle

Alleyne, CH, He, J, Yang, J, Hunter, SB, Cotsonis, G, James, CD & Olson, JJ 1999, 'Analysis of cyclin dependent kinase inhibitors in malignant astrocytomas', International Journal of Oncology, vol. 14, no. 6, pp. 1111-1116.
Alleyne CH, He J, Yang J, Hunter SB, Cotsonis G, James CD et al. Analysis of cyclin dependent kinase inhibitors in malignant astrocytomas. International Journal of Oncology. 1999 Jun 1;14(6):1111-1116.
Alleyne, Cargill Herley ; He, Ju ; Yang, Jing ; Hunter, Stephen B. ; Cotsonis, George ; James, C. David ; Olson, Jeffrey J. / Analysis of cyclin dependent kinase inhibitors in malignant astrocytomas. In: International Journal of Oncology. 1999 ; Vol. 14, No. 6. pp. 1111-1116.
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