Analysis of GNAS mutations in cemento-ossifying fibromas and cemento-osseous dysplasias of the jaws

Milan M. Patel, Jonathan F. Wilkey, Rafik Abdelsayed, Nisha J. D'Silva, Carl Malchoff, Sanjay M. Mallya

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Objectives: It is well established that fibrous dysplasia (FD) is caused by mutations of the Arg201 codon of the GNAS gene. However, the role of GNAS mutation in the pathogenesis of cement-osseous dysplasias (COD) and cemento-ossifying fibromas (COF) is not fully known. In this study, we examined COD and COF for mutations at the Arg201 codon of the GNAS gene. Study design: The study sample included formalin-fixed, paraffin-embedded tissue blocks from 8 COF and 24 COD. We used 2 PCR-RFLP methods to detect mutations at the Arg201 codon of the GNAS gene. Results: Mutations at the Arg201 codon of the GNAS gene were not present in any of the COD and COF examined. Conclusions: GNAS mutations do not play a role in the pathogenesis of COD and COF. This highlights a clear molecular distinction between FD and other histologically similar fibro-osseous lesions of the jaws.

Original languageEnglish (US)
Pages (from-to)739-743
Number of pages5
JournalOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology
Volume109
Issue number5
DOIs
StatePublished - May 2010

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology
  • Dentistry(all)

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