Objectives: It is well established that fibrous dysplasia (FD) is caused by mutations of the Arg201 codon of the GNAS gene. However, the role of GNAS mutation in the pathogenesis of cement-osseous dysplasias (COD) and cemento-ossifying fibromas (COF) is not fully known. In this study, we examined COD and COF for mutations at the Arg201 codon of the GNAS gene. Study design: The study sample included formalin-fixed, paraffin-embedded tissue blocks from 8 COF and 24 COD. We used 2 PCR-RFLP methods to detect mutations at the Arg201 codon of the GNAS gene. Results: Mutations at the Arg201 codon of the GNAS gene were not present in any of the COD and COF examined. Conclusions: GNAS mutations do not play a role in the pathogenesis of COD and COF. This highlights a clear molecular distinction between FD and other histologically similar fibro-osseous lesions of the jaws.
|Original language||English (US)|
|Number of pages||5|
|Journal||Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology|
|State||Published - May 2010|
ASJC Scopus subject areas
- Oral Surgery