Analysis of Multiple Bands on Serum Protein Immunofixation Electrophoresis: Challenge in Interpretation of Clonality in a Patient with Light Chain-Predominant Multiple Myeloma

Okechukwu V. Nwogbo, Yulan Jin, Taylor Sliker, Dorian Wilhite, Gurmukh Singh

Research output: Contribution to journalArticlepeer-review

Abstract

Sera from patients with multiple myeloma usually display a single monoclonal immunoglobulin band on serum protein immunofixation electrophoresis. Multiple bands may be seen if the myeloma is bi- or triclonal or if the monoclonal immunoglobulin has rheumatoid factor activity. We describe a patient with light chain-predominant IgA lambda myeloma; the patient's serum displayed 2 spatially distinct bands reacting for alpha heavy and lambda light chains. The methods used to establish monoclonality are addressed.

Original languageEnglish (US)
Pages (from-to)503-508
Number of pages6
JournalLaboratory medicine
Volume52
Issue number5
DOIs
StatePublished - Sep 1 2021

Keywords

  • immune-subtraction
  • light chain predominant multiple myeloma
  • Monoclonal gammopathy
  • multiple bands in SIFE
  • polymeric immunoglobulin chains
  • serum free light chains

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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