Analyse potentieller PERV-infektionen in einem klinisch relevanten schwein-auf-pavian-zelltransplantationsmodell

Translated title of the contribution: Analysis of potential PERV infection in a clinical-relevant pig to baboon xenotransplantation model

C. Templin, A. R. Simon, C. Schröder, M. E. Winkler, G. Laaf, M. Chikobava, V. Z. Agrba, B. A. Lapin, A. Haverich, U. Martin

Research output: Contribution to journalArticle

Abstract

Besides vehement rejection of pig organs, infection risks, especially the risk of porcine endogenous retrovirus (PERV) transmission, represent the main hurdle for clinical introduction of xenotransplantation. Neither retrospective studies on patients nor small animal models mirror settings of clinical xenotransplantation very closely. For this reason, we have analysed the PERV infection risk in a pig-to-baboon xenotransplantation model after conditioning CyP immunosuppression, adsorption of anti-porcine antibodies and inactivation of complement.

Translated title of the contributionAnalysis of potential PERV infection in a clinical-relevant pig to baboon xenotransplantation model
Original languageGerman
Pages (from-to)225-230
Number of pages6
JournalTransplantationsmedizin: Organ der Deutschen Transplantationsgesellschaft
Volume14
Issue number4
StatePublished - Jan 1 2002

Keywords

  • Baboon
  • Infection risk
  • PERV
  • Porcine endogenous retrovirus
  • Xenotransplantation

ASJC Scopus subject areas

  • Transplantation

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    Templin, C., Simon, A. R., Schröder, C., Winkler, M. E., Laaf, G., Chikobava, M., Agrba, V. Z., Lapin, B. A., Haverich, A., & Martin, U. (2002). Analyse potentieller PERV-infektionen in einem klinisch relevanten schwein-auf-pavian-zelltransplantationsmodell. Transplantationsmedizin: Organ der Deutschen Transplantationsgesellschaft, 14(4), 225-230.