Besides vehement rejection of pig organs, infection risks, especially the risk of porcine endogenous retrovirus (PERV) transmission, represent the main hurdle for clinical introduction of xenotransplantation. Neither retrospective studies on patients nor small animal models mirror settings of clinical xenotransplantation very closely. For this reason, we have analysed the PERV infection risk in a pig-to-baboon xenotransplantation model after conditioning CyP immunosuppression, adsorption of anti-porcine antibodies and inactivation of complement.
|Translated title of the contribution||Analysis of potential PERV infection in a clinical-relevant pig to baboon xenotransplantation model|
|Number of pages||6|
|Journal||Transplantationsmedizin: Organ der Deutschen Transplantationsgesellschaft|
|State||Published - Jan 1 2002|
- Infection risk
- Porcine endogenous retrovirus
ASJC Scopus subject areas