Analysis of the RB1 gene in children with retinoblastoma having residential connections to West Cumbria, England

John Kenneth Cowell, J. A. Morris, E. J. Tawn

Research output: Contribution to journalArticle

Abstract

Six of eight cases of retinoblastoma previously identified as having a residential association with West Cumbria, England, in which the Sellafield nuclear installation is situated, were examined for the presence of a constitutional RB1 mutation. No mutations were detected, thus providing strong evidence against an environmental or occupational genotoxic effect causing germline mutations in the parents of these children.

Original languageEnglish (US)
Pages (from-to)89-92
Number of pages4
JournalJournal of Radiological Protection
Volume25
Issue number1
DOIs
StatePublished - Mar 1 2005
Externally publishedYes

Fingerprint

Retinoblastoma
England
mutation
Genes
Mutation
Germ-Line Mutation
gene
Parents
analysis

ASJC Scopus subject areas

  • Energy Engineering and Power Technology
  • Safety, Risk, Reliability and Quality
  • Chemical Health and Safety

Cite this

Analysis of the RB1 gene in children with retinoblastoma having residential connections to West Cumbria, England. / Cowell, John Kenneth; Morris, J. A.; Tawn, E. J.

In: Journal of Radiological Protection, Vol. 25, No. 1, 01.03.2005, p. 89-92.

Research output: Contribution to journalArticle

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