Analysis of the RB1 gene in children with retinoblastoma having residential connections to West Cumbria, England

J. K. Cowell; J. A. Morris; E. J. Tawn

doi:10.1088/0952-4746/25/1/006

Analysis of the RB1 gene in children with retinoblastoma having residential connections to West Cumbria, England

J. K. Cowell, J. A. Morris, E. J. Tawn

Research output: Contribution to journal › Article › peer-review

Abstract

Six of eight cases of retinoblastoma previously identified as having a residential association with West Cumbria, England, in which the Sellafield nuclear installation is situated, were examined for the presence of a constitutional RB1 mutation. No mutations were detected, thus providing strong evidence against an environmental or occupational genotoxic effect causing germline mutations in the parents of these children.

Original language	English (US)
Pages (from-to)	89-92
Number of pages	4
Journal	Journal of Radiological Protection
Volume	25
Issue number	1
DOIs	https://doi.org/10.1088/0952-4746/25/1/006
State	Published - Mar 1 2005
Externally published	Yes

ASJC Scopus subject areas

Waste Management and Disposal
Public Health, Environmental and Occupational Health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1088/0952-4746/25/1/006

Cite this

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abstract = "Six of eight cases of retinoblastoma previously identified as having a residential association with West Cumbria, England, in which the Sellafield nuclear installation is situated, were examined for the presence of a constitutional RB1 mutation. No mutations were detected, thus providing strong evidence against an environmental or occupational genotoxic effect causing germline mutations in the parents of these children.",

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AB - Six of eight cases of retinoblastoma previously identified as having a residential association with West Cumbria, England, in which the Sellafield nuclear installation is situated, were examined for the presence of a constitutional RB1 mutation. No mutations were detected, thus providing strong evidence against an environmental or occupational genotoxic effect causing germline mutations in the parents of these children.

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Analysis of the RB1 gene in children with retinoblastoma having residential connections to West Cumbria, England

Abstract

ASJC Scopus subject areas

UN SDGs

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