Abstract
The organization of membrane-spanning proteins within discrete microdomains is critical for their physiologic function. This is especially important in the heart, where ion transporter and forcetransducing microdomains are responsible for excitation-contraction coupling, anisotropic depolarization, and mechanotransduction. The following review will discuss recent advances in our understanding of the patterning of ion channel and force-transmitting membrane microdomains in cardiomyocytes, focusing on the T-tubule and intercalated disc.
Original language | English (US) |
---|---|
Pages (from-to) | 106-115 |
Number of pages | 10 |
Journal | Journal of Cardiovascular Pharmacology |
Volume | 54 |
Issue number | 2 |
DOIs | |
State | Published - Aug 2009 |
Externally published | Yes |
Keywords
- Adherens junction
- Ankyrin-B
- Ankyrin-G
- Arrhythmogenic right ventricular cardiomyopathy
- Brugada
- Costamere
- Desmosome
- Intercalated disc
- Long QT syndrome
ASJC Scopus subject areas
- Pharmacology
- Cardiology and Cardiovascular Medicine