Ankyrin-based patterning of membrane microdomains: New insights into a novel class of cardiovascular diseases

Kent R. Nilsson, Vann Bennett

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

The organization of membrane-spanning proteins within discrete microdomains is critical for their physiologic function. This is especially important in the heart, where ion transporter and forcetransducing microdomains are responsible for excitation-contraction coupling, anisotropic depolarization, and mechanotransduction. The following review will discuss recent advances in our understanding of the patterning of ion channel and force-transmitting membrane microdomains in cardiomyocytes, focusing on the T-tubule and intercalated disc.

Original languageEnglish (US)
Pages (from-to)106-115
Number of pages10
JournalJournal of Cardiovascular Pharmacology
Volume54
Issue number2
DOIs
StatePublished - Aug 1 2009
Externally publishedYes

Keywords

  • Adherens junction
  • Ankyrin-B
  • Ankyrin-G
  • Arrhythmogenic right ventricular cardiomyopathy
  • Brugada
  • Costamere
  • Desmosome
  • Intercalated disc
  • Long QT syndrome

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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