Ankyrin-based patterning of membrane microdomains: New insights into a novel class of cardiovascular diseases

Kent R. Nilsson, Vann Bennett

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

The organization of membrane-spanning proteins within discrete microdomains is critical for their physiologic function. This is especially important in the heart, where ion transporter and forcetransducing microdomains are responsible for excitation-contraction coupling, anisotropic depolarization, and mechanotransduction. The following review will discuss recent advances in our understanding of the patterning of ion channel and force-transmitting membrane microdomains in cardiomyocytes, focusing on the T-tubule and intercalated disc.

Original languageEnglish (US)
Pages (from-to)106-115
Number of pages10
JournalJournal of Cardiovascular Pharmacology
Volume54
Issue number2
DOIs
StatePublished - Aug 1 2009

Fingerprint

Ankyrins
Membrane Microdomains
Excitation Contraction Coupling
Ion Channels
Cardiac Myocytes
Membrane Proteins
Cardiovascular Diseases
Ions

Keywords

  • Adherens junction
  • Ankyrin-B
  • Ankyrin-G
  • Arrhythmogenic right ventricular cardiomyopathy
  • Brugada
  • Costamere
  • Desmosome
  • Intercalated disc
  • Long QT syndrome

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

Cite this

Ankyrin-based patterning of membrane microdomains : New insights into a novel class of cardiovascular diseases. / Nilsson, Kent R.; Bennett, Vann.

In: Journal of Cardiovascular Pharmacology, Vol. 54, No. 2, 01.08.2009, p. 106-115.

Research output: Contribution to journalReview article

@article{6cea9243487740e1884130fbd313691a,
title = "Ankyrin-based patterning of membrane microdomains: New insights into a novel class of cardiovascular diseases",
abstract = "The organization of membrane-spanning proteins within discrete microdomains is critical for their physiologic function. This is especially important in the heart, where ion transporter and forcetransducing microdomains are responsible for excitation-contraction coupling, anisotropic depolarization, and mechanotransduction. The following review will discuss recent advances in our understanding of the patterning of ion channel and force-transmitting membrane microdomains in cardiomyocytes, focusing on the T-tubule and intercalated disc.",
keywords = "Adherens junction, Ankyrin-B, Ankyrin-G, Arrhythmogenic right ventricular cardiomyopathy, Brugada, Costamere, Desmosome, Intercalated disc, Long QT syndrome",
author = "Nilsson, {Kent R.} and Vann Bennett",
year = "2009",
month = "8",
day = "1",
doi = "10.1097/FJC.0b013e3181b2b6ed",
language = "English (US)",
volume = "54",
pages = "106--115",
journal = "Journal of Cardiovascular Pharmacology",
issn = "0160-2446",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Ankyrin-based patterning of membrane microdomains

T2 - New insights into a novel class of cardiovascular diseases

AU - Nilsson, Kent R.

AU - Bennett, Vann

PY - 2009/8/1

Y1 - 2009/8/1

N2 - The organization of membrane-spanning proteins within discrete microdomains is critical for their physiologic function. This is especially important in the heart, where ion transporter and forcetransducing microdomains are responsible for excitation-contraction coupling, anisotropic depolarization, and mechanotransduction. The following review will discuss recent advances in our understanding of the patterning of ion channel and force-transmitting membrane microdomains in cardiomyocytes, focusing on the T-tubule and intercalated disc.

AB - The organization of membrane-spanning proteins within discrete microdomains is critical for their physiologic function. This is especially important in the heart, where ion transporter and forcetransducing microdomains are responsible for excitation-contraction coupling, anisotropic depolarization, and mechanotransduction. The following review will discuss recent advances in our understanding of the patterning of ion channel and force-transmitting membrane microdomains in cardiomyocytes, focusing on the T-tubule and intercalated disc.

KW - Adherens junction

KW - Ankyrin-B

KW - Ankyrin-G

KW - Arrhythmogenic right ventricular cardiomyopathy

KW - Brugada

KW - Costamere

KW - Desmosome

KW - Intercalated disc

KW - Long QT syndrome

UR - http://www.scopus.com/inward/record.url?scp=74249116009&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=74249116009&partnerID=8YFLogxK

U2 - 10.1097/FJC.0b013e3181b2b6ed

DO - 10.1097/FJC.0b013e3181b2b6ed

M3 - Review article

C2 - 19636256

AN - SCOPUS:74249116009

VL - 54

SP - 106

EP - 115

JO - Journal of Cardiovascular Pharmacology

JF - Journal of Cardiovascular Pharmacology

SN - 0160-2446

IS - 2

ER -