The organization of membrane-spanning proteins within discrete microdomains is critical for their physiologic function. This is especially important in the heart, where ion transporter and forcetransducing microdomains are responsible for excitation-contraction coupling, anisotropic depolarization, and mechanotransduction. The following review will discuss recent advances in our understanding of the patterning of ion channel and force-transmitting membrane microdomains in cardiomyocytes, focusing on the T-tubule and intercalated disc.
- Adherens junction
- Arrhythmogenic right ventricular cardiomyopathy
- Intercalated disc
- Long QT syndrome
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine