Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids

Koichi Node, Yuqing Huo, Xiulu Ruan, Baichun Yang, Martin Spiecker, Klaus Ley, Darryl C. Zeldin, James K. Liao

Research output: Contribution to journalArticle

848 Citations (Scopus)

Abstract

The epoxyeicosatrienoic acids (EETs) are products of cytochrome P450 epoxygenases that have vasodilatory properties similar to that of endothelium-derived hyperpolarizing factor. The cytochrome P450 isoform CYP2J2 was cloned and identified as a potential source of EETs in human endothelial cells. Physiological concentrations of EETs or overexpression of CYP2J2 decreased cytokine-induced endothelial cell adhesion molecule expression, and EETs prevented leukocyte adhesion to the vascular wall by a mechanism involving inhibition of transcription factor NF-κB and IκB kinase. The inhibitory effects of EETs were independent of their membrane- hyperpolarizing effects, suggesting that these molecules play an important nonvasodilatory role in vascular inflammation.

Original languageEnglish (US)
Pages (from-to)1276-1279
Number of pages4
JournalScience
Volume285
Issue number5431
DOIs
StatePublished - Aug 20 1999

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Eicosanoids
Cytochrome P-450 Enzyme System
Blood Vessels
Anti-Inflammatory Agents
Endothelial Cells
Cell Adhesion Molecules
Endothelium
Protein Isoforms
Leukocytes
Transcription Factors
Phosphotransferases
Cytokines
Inflammation
Acids
Membranes
arachidonate epoxygenase

ASJC Scopus subject areas

  • General

Cite this

Node, K., Huo, Y., Ruan, X., Yang, B., Spiecker, M., Ley, K., ... Liao, J. K. (1999). Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids. Science, 285(5431), 1276-1279. https://doi.org/10.1126/science.285.5431.1276

Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids. / Node, Koichi; Huo, Yuqing; Ruan, Xiulu; Yang, Baichun; Spiecker, Martin; Ley, Klaus; Zeldin, Darryl C.; Liao, James K.

In: Science, Vol. 285, No. 5431, 20.08.1999, p. 1276-1279.

Research output: Contribution to journalArticle

Node, K, Huo, Y, Ruan, X, Yang, B, Spiecker, M, Ley, K, Zeldin, DC & Liao, JK 1999, 'Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids', Science, vol. 285, no. 5431, pp. 1276-1279. https://doi.org/10.1126/science.285.5431.1276
Node, Koichi ; Huo, Yuqing ; Ruan, Xiulu ; Yang, Baichun ; Spiecker, Martin ; Ley, Klaus ; Zeldin, Darryl C. ; Liao, James K. / Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids. In: Science. 1999 ; Vol. 285, No. 5431. pp. 1276-1279.
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