Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids

Koichi Node, Yuqing Huo, Xiulu Ruan, Baichun Yang, Martin Spiecker, Klaus Ley, Darryl C. Zeldin, James K. Liao

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Abstract

The epoxyeicosatrienoic acids (EETs) are products of cytochrome P450 epoxygenases that have vasodilatory properties similar to that of endothelium-derived hyperpolarizing factor. The cytochrome P450 isoform CYP2J2 was cloned and identified as a potential source of EETs in human endothelial cells. Physiological concentrations of EETs or overexpression of CYP2J2 decreased cytokine-induced endothelial cell adhesion molecule expression, and EETs prevented leukocyte adhesion to the vascular wall by a mechanism involving inhibition of transcription factor NF-κB and IκB kinase. The inhibitory effects of EETs were independent of their membrane- hyperpolarizing effects, suggesting that these molecules play an important nonvasodilatory role in vascular inflammation.

Original languageEnglish (US)
Pages (from-to)1276-1279
Number of pages4
JournalScience
Volume285
Issue number5431
DOIs
StatePublished - Aug 20 1999

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Cite this

Node, K., Huo, Y., Ruan, X., Yang, B., Spiecker, M., Ley, K., Zeldin, D. C., & Liao, J. K. (1999). Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids. Science, 285(5431), 1276-1279. https://doi.org/10.1126/science.285.5431.1276