Antiandrogenic effect of delta-9-tetrahydrocannabinol in adult castrated rats

S. P. Ghosh, Tapan Kumar Chatterjee, J. J. Ghosh

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In ventral prostate tissues of adult castrated rats, delta-9-tetrahydrocannabinol (THC) at 10 mg/kg for 7 days counteracted the testosterone-induced changes of DNA, RNA and protein content, the tartrate-insensitive form of acid phosphatase, and the isoenzyme variant of acid phosphatase associated with the secretory type enzyme. The results indicate that THC acts anti-androgenically and directly at the level of male accessory sex organs.

Original languageEnglish (US)
Pages (from-to)513-517
Number of pages5
JournalJournal of Reproduction and Fertility
Volume62
Issue number2
DOIs
StatePublished - Jan 1 1981

Fingerprint

Dronabinol
Acid Phosphatase
Male Genitalia
Isoenzymes
Testosterone
Prostate
RNA
DNA
Enzymes
Proteins
tartaric acid

ASJC Scopus subject areas

  • Physiology
  • Embryology
  • Molecular Biology
  • Obstetrics and Gynecology
  • Developmental Biology

Cite this

Antiandrogenic effect of delta-9-tetrahydrocannabinol in adult castrated rats. / Ghosh, S. P.; Chatterjee, Tapan Kumar; Ghosh, J. J.

In: Journal of Reproduction and Fertility, Vol. 62, No. 2, 01.01.1981, p. 513-517.

Research output: Contribution to journalArticle

Ghosh, S. P. ; Chatterjee, Tapan Kumar ; Ghosh, J. J. / Antiandrogenic effect of delta-9-tetrahydrocannabinol in adult castrated rats. In: Journal of Reproduction and Fertility. 1981 ; Vol. 62, No. 2. pp. 513-517.
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