Abstract
The susceptibility of Aspergillus fumigatus to a series of α,β- unsaturated styryl ketones known to be thiol-alkylators was examined, and the results were compared with those obtained for Candida albicans. Among 13 compounds used in our study, one (designated NC1110) inhibited the growth of A. fumigatus completely at low concentrations (minimum inhibitory concentration = 32 μM). Structure-activity analysis of these compounds indicated that the electron attracting property as well as the overall hydrophobicity of the compounds are important parameters for their antifungal activity. These preliminary results suggest that further modification of these molecules to enhance their hydrophobicity and the electron attracting property may result in more active compounds with improved antifungal activity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 361-365 |
| Number of pages | 5 |
| Journal | Indian Journal of Experimental Biology |
| Volume | 35 |
| Issue number | 4 |
| State | Published - Apr 1 1997 |
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ASJC Scopus subject areas
- Bioengineering
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Antifungal activity of conjugated styryl ketones. / Manavathu, Elias K.; McDonald, Louise A.; Gunasekaran, Suresh; Gunasekaran, Muthukumaran.
In: Indian Journal of Experimental Biology, Vol. 35, No. 4, 01.04.1997, p. 361-365.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antifungal activity of conjugated styryl ketones
AU - Manavathu, Elias K.
AU - McDonald, Louise A.
AU - Gunasekaran, Suresh
AU - Gunasekaran, Muthukumaran
PY - 1997/4/1
Y1 - 1997/4/1
N2 - The susceptibility of Aspergillus fumigatus to a series of α,β- unsaturated styryl ketones known to be thiol-alkylators was examined, and the results were compared with those obtained for Candida albicans. Among 13 compounds used in our study, one (designated NC1110) inhibited the growth of A. fumigatus completely at low concentrations (minimum inhibitory concentration = 32 μM). Structure-activity analysis of these compounds indicated that the electron attracting property as well as the overall hydrophobicity of the compounds are important parameters for their antifungal activity. These preliminary results suggest that further modification of these molecules to enhance their hydrophobicity and the electron attracting property may result in more active compounds with improved antifungal activity.
AB - The susceptibility of Aspergillus fumigatus to a series of α,β- unsaturated styryl ketones known to be thiol-alkylators was examined, and the results were compared with those obtained for Candida albicans. Among 13 compounds used in our study, one (designated NC1110) inhibited the growth of A. fumigatus completely at low concentrations (minimum inhibitory concentration = 32 μM). Structure-activity analysis of these compounds indicated that the electron attracting property as well as the overall hydrophobicity of the compounds are important parameters for their antifungal activity. These preliminary results suggest that further modification of these molecules to enhance their hydrophobicity and the electron attracting property may result in more active compounds with improved antifungal activity.
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UR - http://www.scopus.com/inward/citedby.url?scp=0031427461&partnerID=8YFLogxK
M3 - Article
C2 - 9315235
AN - SCOPUS:0031427461
VL - 35
SP - 361
EP - 365
JO - Journal of scientific & industrial research. C. Biological sciences
JF - Journal of scientific & industrial research. C. Biological sciences
SN - 0019-5189
IS - 4
ER -