Antifungal activity of conjugated styryl ketones

Elias K. Manavathu, Louise A. McDonald, Suresh Gunasekaran, Muthukumaran Gunasekaran

Research output: Contribution to journalArticle

Abstract

The susceptibility of Aspergillus fumigatus to a series of α,β- unsaturated styryl ketones known to be thiol-alkylators was examined, and the results were compared with those obtained for Candida albicans. Among 13 compounds used in our study, one (designated NC1110) inhibited the growth of A. fumigatus completely at low concentrations (minimum inhibitory concentration = 32 μM). Structure-activity analysis of these compounds indicated that the electron attracting property as well as the overall hydrophobicity of the compounds are important parameters for their antifungal activity. These preliminary results suggest that further modification of these molecules to enhance their hydrophobicity and the electron attracting property may result in more active compounds with improved antifungal activity.

Original languageEnglish (US)
Pages (from-to)361-365
Number of pages5
JournalIndian Journal of Experimental Biology
Volume35
Issue number4
StatePublished - Apr 1 1997

Fingerprint

Aspergillus fumigatus
Hydrophobicity
Ketones
Hydrophobic and Hydrophilic Interactions
Electrons
Candida
Aspergillus
Alkylating Agents
Microbial Sensitivity Tests
Candida albicans
Sulfhydryl Compounds
Molecules
Growth

ASJC Scopus subject areas

  • Bioengineering

Cite this

Manavathu, E. K., McDonald, L. A., Gunasekaran, S., & Gunasekaran, M. (1997). Antifungal activity of conjugated styryl ketones. Indian Journal of Experimental Biology, 35(4), 361-365.

Antifungal activity of conjugated styryl ketones. / Manavathu, Elias K.; McDonald, Louise A.; Gunasekaran, Suresh; Gunasekaran, Muthukumaran.

In: Indian Journal of Experimental Biology, Vol. 35, No. 4, 01.04.1997, p. 361-365.

Research output: Contribution to journalArticle

Manavathu, EK, McDonald, LA, Gunasekaran, S & Gunasekaran, M 1997, 'Antifungal activity of conjugated styryl ketones', Indian Journal of Experimental Biology, vol. 35, no. 4, pp. 361-365.
Manavathu EK, McDonald LA, Gunasekaran S, Gunasekaran M. Antifungal activity of conjugated styryl ketones. Indian Journal of Experimental Biology. 1997 Apr 1;35(4):361-365.
Manavathu, Elias K. ; McDonald, Louise A. ; Gunasekaran, Suresh ; Gunasekaran, Muthukumaran. / Antifungal activity of conjugated styryl ketones. In: Indian Journal of Experimental Biology. 1997 ; Vol. 35, No. 4. pp. 361-365.
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