Antigen-induced production of lymphokines by human T cell clones specific for hepatitis B surface antigen

Esteban Celis, Richard W. Miller, Chang Tse wen

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The secretion of gamma-interferon (IFN-γ), Interleukin-2 (IL-2), and B cell growth factor (BCGF) by human T cell clones specific for hepatitis B surface antigen (HBsAg) was examined. Antigenic stimulation by HBsAg but not by influenza A virus resulted in IFN-γ and BCGF synthesis by the T cell clones. No detectable amounts of IL-2 were obtained in the supernatants of any of the HBsAg-specific T cell clones when cultured in the presence or absence of antigen. IFN-γ and BCGF were produced, even when cell proliferation was inhibited, suggesting that the secretion of these T cell factors occured regardless of cell proliferation. The significance of the various factors in the immune response against hepatitis B virus infection is discussed.

Original languageEnglish (US)
Pages (from-to)229-237
Number of pages9
JournalHuman Immunology
Volume11
Issue number4
DOIs
StatePublished - Dec 1984

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Lymphokines
Hepatitis B Surface Antigens
Interleukin-2
Clone Cells
T-Lymphocytes
Antigens
B-Lymphocytes
Cell Proliferation
TCF Transcription Factors
Influenza A virus
Immunologic Factors
Virus Diseases
Hepatitis B virus
Interferon-gamma
Intercellular Signaling Peptides and Proteins

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Antigen-induced production of lymphokines by human T cell clones specific for hepatitis B surface antigen. / Celis, Esteban; Miller, Richard W.; Tse wen, Chang.

In: Human Immunology, Vol. 11, No. 4, 12.1984, p. 229-237.

Research output: Contribution to journalArticle

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