TY - JOUR
T1 - Antimicrobial Ionic Liquid-Based Materials for Biomedical Applications
AU - Nikfarjam, Nasser
AU - Ghomi, Matineh
AU - Agarwal, Tarun
AU - Hassanpour, Mahnaz
AU - Sharifi, Esmaeel
AU - Khorsandi, Danial
AU - Ali Khan, Moonis
AU - Rossi, Filippo
AU - Rossetti, Arianna
AU - Nazarzadeh Zare, Ehsan
AU - Rabiee, Navid
AU - Afshar, Davoud
AU - Vosough, Massoud
AU - Kumar Maiti, Tapas
AU - Mattoli, Virgilio
AU - Lichtfouse, Eric
AU - Tay, Franklin R.
AU - Makvandi, Pooyan
N1 - Publisher Copyright:
© 2021 The Authors. Advanced Functional Materials published by Wiley-VCH GmbH
PY - 2021/10/14
Y1 - 2021/10/14
N2 - Excessive and unwarranted administration of antibiotics has invigorated the evolution of multidrug-resistant microbes. There is, therefore, an urgent need for advanced active compounds. Ionic liquids with short-lived ion-pair structures are highly tunable and have diverse applications. Apart from their unique physicochemical features, the newly discovered biological activities of ionic liquids have fascinated biochemists, microbiologists, and medical scientists. In particular, their antimicrobial properties have opened new vistas in overcoming the current challenges associated with combating antibiotic-resistant pathogens. Discussions regarding ionic liquid derivatives in monomeric and polymeric forms with antimicrobial activities are presented here. The antimicrobial mechanism of ionic liquids and parameters that affect their antimicrobial activities, such as chain length, cation/anion type, cation density, and polymerization, are considered. The potential applications of ionic liquids in the biomedical arena, including regenerative medicine, biosensing, and drug/biomolecule delivery, are presented to stimulate the scientific community to further improve the antimicrobial efficacy of ionic liquids.
AB - Excessive and unwarranted administration of antibiotics has invigorated the evolution of multidrug-resistant microbes. There is, therefore, an urgent need for advanced active compounds. Ionic liquids with short-lived ion-pair structures are highly tunable and have diverse applications. Apart from their unique physicochemical features, the newly discovered biological activities of ionic liquids have fascinated biochemists, microbiologists, and medical scientists. In particular, their antimicrobial properties have opened new vistas in overcoming the current challenges associated with combating antibiotic-resistant pathogens. Discussions regarding ionic liquid derivatives in monomeric and polymeric forms with antimicrobial activities are presented here. The antimicrobial mechanism of ionic liquids and parameters that affect their antimicrobial activities, such as chain length, cation/anion type, cation density, and polymerization, are considered. The potential applications of ionic liquids in the biomedical arena, including regenerative medicine, biosensing, and drug/biomolecule delivery, are presented to stimulate the scientific community to further improve the antimicrobial efficacy of ionic liquids.
KW - antibacterial mechanism
KW - chain length
KW - drug delivery
KW - imidazolium
KW - ionic liquid
KW - quaternary ammonium
KW - tissue regeneration
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U2 - 10.1002/adfm.202104148
DO - 10.1002/adfm.202104148
M3 - Review article
AN - SCOPUS:85110965699
SN - 1616-301X
VL - 31
JO - Advanced Functional Materials
JF - Advanced Functional Materials
IS - 42
M1 - 2104148
ER -